Suppression of β-Cell Apoptosis from H2O2-Induced Oxidative Stress in MIN6 cells using Methyl Gallate
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Published:2022
Issue:1
Volume:44
Page:84-84
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ISSN:0253-5106
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Container-title:Journal of the chemical society of pakistan
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language:
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Short-container-title:JCS Pak
Author:
Tasneef Azam Tasneef Azam,Fouzia Noreen Fouzia Noreen,Bina S Siddiqui Bina S Siddiqui,Rahman M Hafizur Rahman M Hafizur,Sabira Begum Sabira Begum
Abstract
A major parameter for diabetic relevant diseases and hyperglycemia is the β-cell apoptosis. Anti diabetic drugs used widely these days chiefly target to lower hyperglycemia along with prevention of β-cells from apoptosis. In this study three natural products methyl gallate, syringic acid, and butanedioic acid from Myricaria germanica were analyzed for β-cell protection. Methyl gallate provided significant β-cell protection from H2O2-induced oxidative stress mediated apoptosis in MIN6 cells at 50 μM (95.5% and#177; 16.0 vs 57.6% and#177; 1.1) and at 100 μM (85.5% and#177; 7.0 vs 57.6% and#177; 1.1) concentrations.
Publisher
Chemical Society of Pakistan
Subject
General Chemistry