Synthesis, Characterization, Enhanced Solubility and Antioxidant Activity of the Inclusion Compound of 2-Amino-N-o-tolyl-benzamide and Beta Cyclodextrin
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Published:2024
Issue:1
Volume:46
Page:93-93
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ISSN:0253-5106
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Container-title:Journal of the chemical society of pakistan
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language:
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Short-container-title:JCS Pak
Author:
A Ben Hadj Amor A Ben Hadj Amor,A Mezni and R Abderrahim A Mezni and R Abderrahim
Abstract
The objectives of this research, were to study the effect of beta cyclodextrin on the enhancement of the solubility and the antioxidant activity of 2-Amino-N-o-tolyl-benzamide (ATB). ATB was obtained by a new synthesis method and used to form inclusion compound macromolecule with -CD. The characterization of the ATB and the complex were subsequently established by FT-IR; 1H NMR; 13C NMR; NMR 2D spectra and XRD. The optical activity was measured. The interaction of β-CD and ATB was also analyzed by UV-Vis spectroscopy in order to determine the formation constant. The stoichiometry of the complex was 1:1. Furthermore, the solubility and antioxidant activity of ATB were significantly enhanced upon complexation with β CD.
Publisher
Chemical Society of Pakistan