TFA Mediated Ring-Opening for Evodiamine to Prepare Novel Tryptamine Derivatives
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Published:2024
Issue:1
Volume:46
Page:70-70
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ISSN:0253-5106
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Container-title:Journal of the chemical society of pakistan
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language:
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Short-container-title:JCS Pak
Author:
Hongzhuo Wei Hongzhuo Wei,XH Wang XH Wang,Weihang Guo Weihang Guo,Y H Wang and C K Zhao Y H Wang and C K Zhao
Abstract
A convenient feasible protocol was developed for the preparation of novel tryptamine derivatives from evodiamine. After the general alkylation in N-13 and followed by the treatment of TFA in chloroform, a series of tryptamine derivatives 4a-i were successfully synthesized in a good yield, which were immediately cyclized to form alcohol 5 in the condition of NaOH/methanol.
Publisher
Chemical Society of Pakistan