Assessment of polygenic risk of hypertension-Reference-Cited by-同舟云学术

Assessment of polygenic risk of hypertension

Published:2023-01-19 Issue:12 Volume:21 Page:3464
ISSN:2619-0125
Container-title:Cardiovascular Therapy and Prevention
language:
Short-container-title:Cardiovasc Ther Prev

Author:

Limonova A. S.¹^ORCID,Ershova A. I.¹^ORCID,Kiseleva A. V.¹^ORCID,Ramensky V. E.²^ORCID,Vyatkin Yu. V.³^ORCID,Kutsenko V. A.⁴^ORCID,Meshkov A. N.⁵^ORCID,Drapkina O. M.¹^ORCID

Affiliation:

1. National Medical Research Center for Therapy and Preventive Medicine

2. National Medical Research Center for Therapy and Preventive Medicine; Lomonosov Moscow State University

3. National Medical Research Center for Therapy and Preventive Medicine; Novosibirsk National Research State University

4. National Medical Research Center for Therapy and Preventive Medicine; Faculty of Mechanics and Mathematics, Lomonosov Moscow State University

5. National Medical Research Center for Therapy and Preventive Medicine; Pirogov Russian National Research Medical University

Abstract

Hypertension (HTN) is a leading risk factor for the development of cardiovascular diseases. In recent decades, the rapid development of genetic tests, in particular genome-wide association study (GWAS), has made it possible to identify hundreds of nucleotide sequence variants associated with the development of HTN. One approach to improve the predictive power of genetic testing is to combine information about many nucleotide sequence variants into a single risk assessment system, often referred to as a genetic risk score. Within the framework of this review, the most significant publications on the study of the genetic risk score for HTN will be considered, and the features of their development and application will be discussed.

Publisher

Silicea - Poligraf, LLC

Subject

Cardiology and Cardiovascular Medicine,Education

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