Dyslipidemia in the Russian Federation: population data, associations with risk factors-Reference-Cited by-同舟云学术

Dyslipidemia in the Russian Federation: population data, associations with risk factors

Published:2023-12-28 Issue:8S Volume:22 Page:3791
ISSN:2619-0125
Container-title:Cardiovascular Therapy and Prevention
language:
Short-container-title:Cardiovasc Ther Prev

Author:

Drapkina O. M.¹^ORCID,Imaeva A. E.¹^ORCID,Kutsenko V. A.²^ORCID,Kapustina A. V.¹^ORCID,Balanova Yu. A.¹^ORCID,Maksimov S. A.¹^ORCID,Muromtseva G. A.¹^ORCID,Kotova M. B.¹^ORCID,Karamnova N. S.¹^ORCID,Evstifeeva S. E.¹^ORCID,Litinskaya O. A.¹^ORCID,Pokrovskaya M. S.¹^ORCID,Imaeva N. A.¹^ORCID,Filichkina E. M.²^ORCID,Ivlev O. E.¹^ORCID,Svinin G. E.¹^ORCID,Gomanova L. I.¹^ORCID,Doludin Yu. V.¹^ORCID,Efimova I. A.¹^ORCID,Borisova A. L.¹^ORCID,Nazarov B. M.³^ORCID,Yarovaya E. B.²^ORCID,Repkina T. V.⁴^ORCID,Gonoshilova T. O.⁴^ORCID,Kudryavtsev A. V.⁵^ORCID,Belova N. I.⁵^ORCID,Shagrov L. L.⁵^ORCID,Samotrueva M. A.⁶^ORCID,Yasenyavskaya A. L.⁶^ORCID,Chernysheva E. N.⁶^ORCID,Glukhovskaya S. V.⁷^ORCID,Levina I. A.⁷^ORCID,Shirshova E. A.⁷^ORCID,Dorzhieva E. B.⁸^ORCID,Urbanova E. Z.⁸^ORCID,Borovkova N. Yu.⁹^ORCID,Kurashin V. K.⁹^ORCID,Tokareva A. S.⁹^ORCID,Ragino Yu. I.¹⁰^ORCID,Simonova G. I.¹⁰^ORCID,Shramko V. S.¹⁰^ORCID,Nikulin V. N.¹¹^ORCID,Aslyamov O. R.¹¹^ORCID,Khokhlova G. V.¹¹^ORCID,Solovyova A. V.¹²^ORCID,Rodionov A. A.¹²^ORCID,Kryachkova O. V.¹²^ORCID,Shamurova Yu. Yu.¹³^ORCID,Tantsyreva I. V.¹³^ORCID,Baryshnikova I. N.¹³^ORCID,Ataev M. G.¹⁴^ORCID,Radjabov M. O.¹⁴^ORCID,Isakhanova M. M.¹⁴^ORCID,Umetov M. A.¹⁵^ORCID,Elgarova L. V.¹⁵^ORCID,Khakuasheva I. A.¹⁵^ORCID,Yamashkina E. I.¹⁶^ORCID,Esina M. V.¹⁶^ORCID,Kunyaeva T. A.¹⁷^ORCID,Nikitina A. M.¹⁸^ORCID,Savvina N. V.¹⁹^ORCID,Spiridonova Yu. E.¹⁸^ORCID,Naumova E. A.²⁰^ORCID,Keskinov A. A.²¹^ORCID,Yudin V. S.²¹^ORCID,Yudin S. M.²¹^ORCID,Kontsevaya A. V.¹^ORCID,Shalnova S. A.¹^ORCID

Affiliation:

1. National Medical Research Center for Therapy and Preventive Medicine

2. National Medical Research Center for Therapy and Preventive Medicine; Lomonosov Moscow State University

3. City Polyclinic № 109

4. Regional Center for Public Health and Medical Prevention

5. Northern State Medical University

6. Astrakhan State Medical University

7. Sverdlovsk Regional Medical College

8. Boyanov Center for Public Health and Medical Prevention

9. Privolzhsky Research Medical University

10. Research Institute of Internal and Preventive Medicine — branch of the Institute of Cytology and Genetics

11. Orenburg Regional Center for Public Health and Medical Prevention

12. Tver State Medical University

13. South Ural State Medical University

14. Abusuev Research Institute of Environmental Medicine, Dagestan State Medical University

15. Berbekov Kabardino-Balkarian State University

16. Ogarev Mordovian State University

17. Ogarev Mordovian State University; Mordovian Republican Central Clinical Hospital

18. Republican Center for Public Health and Medical Prevention

19. Ammosov North-Eastern Federal University

20. Republican Center for Public Health and Medical Prevention, Exercise therapy and Sports Medicine

21. Center for Strategic Planning and Management of Biomedical Health Risks

Abstract

Aim. To study the prevalence of dyslipidemias and their association with various risk factors in the Russian population of men and women aged 35-74 years in 2020-2022.Material and methods. This work was carried out as part of the Epidemiology of Cardiovascular Diseases and their Risk Factors in Regions of Russian Federation-3 (ESSE-RF3) study. The sample included 28731 men and women aged 35-74 years living in 15 Russian regions. Hypercholesterolemia (HC) was diagnosed with total cholesterol (TC) ≥5,0 mmol/l, while elevated low-density lipoprotein cholesterol (LDL-C) was considered ≥3,0 mmol/l, hypertriglyceridemia — with triglyceride levels ≥1,7 mmol/l, reduced high-density lipoprotein cholesterol (HDL-C) <1,0 mmol/l in men and <1,2 mmol/l in women. Associations were assessed using logistic regression after adjustment for socio-demographic characteristics, drinking status, presence of hypertension (HTN) and stroke.Results. The prevalence of hypertriglyceridemia in the Russian Federation in 2020-2022 was 58,8%, hypertriglyceridemia — 32,2%. The incidence of lipid-lowering therapy increased with age from 1% in the group of 35-44 years to 16% in the group of 65-74 years. On average, only 7,6% of study participants received lipid-lowering therapy. Significant associations of HC with HTN, obesity and alcohol abuse were identified. Similar results were obtained for elevated LDL-C levels, with the exception of alcohol abuse. In turn, a reduced HDL-C level was significantly associated with the lack of higher education, marriage, physical activity, smoking and the presence of diseases.Conclusion. The prevalence of lipid disorders in the Russian Federation in 2020-2022 remained at a high level. These disorders occurred more often in women, and they were better informed about their cholesterol levels and more often received lipid-lowering therapy. HTN, obesity, and some behavioral and social risk factors were associated with dyslipidemia.

Publisher

Silicea - Poligraf, LLC

Reference37 articles.

1. Karr S. Epidemiology and management of hyperlipidemia. Am J Manag Care. 2017;23(9 Suppl):139-48.

2. Libby P, Buring JE, Badimon L, et al. Atherosclerosis. Nat Rev Dis Primers. 2019;5:56. doi:10.1038/s41572-019-0106-z.

3. Institute for Health Metrics and Evaluation. Findings from the Global Burden of Disease Study 2017. Seattle, WA: IHME. 2018;1-25.

4. Kontsevaya AV, Balanova YuA, Imaeva AE, et al. Economic burden of hypercholesterolemia in the Russian Federation. Rational Pharmacotherapy in Cardiology. 2018;14(3):393-401. (In Russ.) doi:10.20996/1819-6446-2018-14-3-393-401.

5. NCD Risk Factor Collaboration (NCD-RisC). Repositioning of the global epicentre of non-optimal cholesterol. Nature. 2020;582:73-7. doi:10.1038/s41586-020-2338-1.