Dynamics of magnesemia levels, structural-functional heart parameters and arrhythmia syndrome features in patients with myocardial infarction and undifferentiated connective tissue dysplasia against the background of drug correction with magnesium

Abstract

Aim. To assess the relationship of serum magnesium levels with the structural-functional heart parameters and the arrhythmic syndrome features in patients with myocardial infarction (MI) and undifferentiated connective tissue dysplasia (UCTD) against the background of drug correction with magnesium.Material and methods. The study included 112 patients with Q-wave MI. Group I (n=22) consisted of patients with MI and UCTD, who, in addition to the standard basic therapy, from 1st day of IM took the magnesium drug. Group II (n=30) — patients with MI and UCTD who received only basic therapy. Group III (n=60) — patients with MI without UCTD who received standard basic therapy. The control group (n=32) — patients without cardiovascular pathology and without UCTD. For assessment we used clinical and phenotypic examinations, echocardiography and daily monitoring of the electrocardiogram, determination of serum magnesium level in the course of MI.Results. We observed a decrease in serum magnesium level in patients with MI in all study groups on the 1st day of MI. Moreover, this tendency persisted for 28 days in the II and III groups. In the first group of patients against the background of the medical correction, an increase in the magnesium level was observed by the 28th day of MI. MI patients with UCTD revealed a more pronounced increase of left ventricular cavity dimensions, a decrease in its pumping ability. We also noted a tendency to a less pronounced increase in the left ventricular mass index compared with the group of patients with MI without UCTD. In addition, the development of MI in patients with UCTD compared with patients without UCTD is characterized by a higher frequency of paroxysmal supraventricular rhythm disturbances and paroxysmal ventricular tachycardia. Magnesium addition to MI treatment in patients with UCTD reduces the frequency of supraventricular arrhythmias.Conclusion. In patients with MI, which occur on the background of UCTD, the initially existing hypomagnesaemia is associated with the development of a disadaptive version of the post-infarction cardiac remodeling. Magnesium use in patients with MI and UCTD helps to reduce the severity of hypomagnesaemia and the frequency of supraventricular cardiac rhythm disorders.