COMBINATION OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS AND CALCIUM CHANNEL BLOCKERS IN HYPERTENSIVE PATIENTS WITH HEART FAILURE AND PRESERVED SYSTOLIC FUNCTION: IS THERE A PLACE FOR AN INFORMED CHOICE?

Author:

Zhirov I. V.1,Nikolaeva O. A.1,Tereshchenko S. N.1

Affiliation:

1. A.L. Myasnikov Research Institute of Cardiology, Russian Cardiology Scientific and Clinical Complex, Moscow

Abstract

The authors present the data on the potential of the combination of angiotensin-converting enzyme inhibitors and calcium channel antagonists in the treatment of hypertensive patients with chronic heart failure and preserved left ventricular ejection fraction. The informed choice of lisinopril, as a component of such a combination, is justified. 

Publisher

Silicea - Poligraf, LLC

Subject

Cardiology and Cardiovascular Medicine

Reference23 articles.

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2. Sanderson JE. Heart failure with a normal ejection fraction. Heart 2007; 93:155–8.

3. Mareev V, et al. EPOCHE-CHF. J Heart Failure 2011; 12 (5): 254–62. Russian (Mareev V.Yu. i dr. EPOKhA-KhSN. Serdechnaya Nedostatochnost' 2011; 12 (5): 254–62).

4. ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012. European Heart J 2012:33; 1787–847.

5. Fernandez JH, Hayashi MAF, Camargo ACM, Neshich G. Strucural basis of the lisinopril-binding specificity in N- and C-domains of human somatic ACE. Biochem Biophys Res Communic 2003; 308: 219–26.

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