Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month follow-up-Reference-Cited by-同舟云学术

Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month follow-up

Published:2021-11-22 Issue:10 Volume:26 Page:4708
ISSN:2618-7620
Container-title:Russian Journal of Cardiology
language:
Short-container-title:Russ J Cardiol

Author:

Arutyunov G. P.¹^ORCID,Tarlovskaya E. I.²^ORCID,Arutyunov A. G.¹^ORCID,Belenkov Yu. N.³^ORCID,Konradi A. O.⁴^ORCID,Lopatin Yu. M.⁵^ORCID,Rebrov A. P.⁶^ORCID,Tereshchenko S. N.⁷^ORCID,Chesnikova A. I.⁸^ORCID,Hayrapetyan H. G.⁹^ORCID,Babin A. P.¹⁰,Bakulin I. G.¹¹^ORCID,Bakulina N. V.¹¹^ORCID,Balykova L. A.¹²^ORCID,Blagonravova A. S.¹³^ORCID,Boldina M. V.¹³^ORCID,Vaisberg A. R.¹³^ORCID,Galyavich A. S.¹⁴^ORCID,Gomonova V. V.¹¹^ORCID,Grigorieva N. Yu.¹⁵^ORCID,Gubareva I. V.¹⁶^ORCID,Demko I. V.¹⁷^ORCID,Evzerikhina A. V.¹⁸,Zharkov A. V.¹⁹^ORCID,Kamilova U. K.²⁰^ORCID,Kim Z. F.²¹^ORCID,Kuznetsova T. Yu.²²^ORCID,Lareva N. V.²³^ORCID,Makarova E. V.²⁴^ORCID,Malchikova S. V.²⁵^ORCID,Nedogoda S. V.⁵^ORCID,Petrova M. M.²⁶^ORCID,Pochinka I. G.²⁷^ORCID,Protasov K. V.²⁸^ORCID,Protsenko D. N.²⁹^ORCID,Ruzanau D. Yu.³⁰^ORCID,Sayganov S. A.¹¹^ORCID,Sarybaev A. Sh.³¹^ORCID,Selezneva N. M.¹²^ORCID,Sugraliev A. B.³²^ORCID,Fomin I. V.¹³^ORCID,Khlynova O. V.³³^ORCID,Chizhova O. Yu.¹¹^ORCID,Shaposhnik I. I.³⁴^ORCID,Shchukarev D. A.¹⁹,Abdrahmanova A. K.³⁵^ORCID,Avetisian S. A.³⁶,Avoyan H. G.⁹^ORCID,Azarian K. K.⁹,Aimakhanova G. T.³²,Ayipova D. A.³¹,Akunov A. Ch.³¹,Alieva M. K.¹¹^ORCID,Aparkina A. V.⁶^ORCID,Aruslanova O. R.³⁷^ORCID,Ashina E. Yu.¹³^ORCID,Badina O. Yu.³⁸^ORCID,Barisheva O. Yu.²²^ORCID,Batluk T. I.³⁹^ORCID,Batchayeva A. S.⁴⁰,Bashkinov R. A.⁴¹^ORCID,Bitieva A. M.¹¹^ORCID,Bikhteyev I. U.¹¹^ORCID,Borodulina N. A.³⁷^ORCID,Bragin M. V.¹¹^ORCID,Budu A. M.⁴²,Bykova G. A.³³^ORCID,Vagapova K. R.⁴³,Varlamova D. D.²²^ORCID,Vezikova N. N.²²^ORCID,Verbitskaya E. A.⁴⁴^ORCID,Vilkova O. E.¹⁵^ORCID,Vinnikova E. A.¹¹^ORCID,Vustina V. V.⁴⁵^ORCID,Gаlova E. A.¹³^ORCID,Genkel V. V.³⁴^ORCID,Gorshenina E. I.¹²,Grigorieva E. V.⁶^ORCID,Gubareva E. Yu.¹⁶^ORCID,Dabylova G. M.³²,Demchenko I. A.¹⁶,Dolgikh O. Yu.⁴⁶,Duyshobayev M. Y.³¹,Evdokimov D. S.⁴⁷^ORCID,Egorova K. E.⁴⁸^ORCID,Ermilova A. N.⁴⁹^ORCID,Zheldybayeva A. E.³²,Zarechnova N. V.³⁸,Zimina Yu. D.⁵⁰^ORCID,Ivanova S. Yu.⁵¹^ORCID,Ivanchenko E. Yu.¹³^ORCID,Ilina M. V.⁵²^ORCID,Kazakovtseva M. V.²⁵^ORCID,Kazymova E. V.⁵³,Kalinina Yu. S.²⁶^ORCID,Kamardina N. A.³⁸,Karachenova A. M.²³^ORCID,Karetnikov I. A.⁵⁴^ORCID,Karoli N. A.⁶^ORCID,Karsiev M. K.¹¹^ORCID,Кaskaeva D. S.²⁶^ORCID,Kasymova K. F.⁵⁵^ORCID,Kerimbekova Zh. B.³¹,Kerimova A. Sh.⁵⁶^ORCID,Kim E. S.⁵⁷,Kiseleva N. V.⁵⁸^ORCID,Klimenko D. A.¹⁶,Klimova A. V.⁵⁹^ORCID,Kovalishena O. V.¹³^ORCID,Kolmakova E. V.¹¹,Kolchinskaya T. P.⁶⁰,Kolyadich M. I.⁶¹^ORCID,Kondriakova O. V.¹⁶^ORCID,Konoval M. P.¹¹^ORCID,Konstantinov D. Yu.¹⁶^ORCID,Konstantinova E. A.¹⁶^ORCID,Kordukova V. A.¹³,Koroleva E. V.⁶²,Kraposhina A. Yu.¹⁷^ORCID,Kriukova T. V.⁶³,Kuznetsova A. S.³⁴^ORCID,Kuzmina T. Yu.²⁶^ORCID,Kuzmichev K. V.⁶⁴,Kulchoroeva Ch. K.³¹^ORCID,Kuprina T. V.²²^ORCID,Kouranova I. M.⁶⁵,Kurenkova L. V.⁶⁶,Kurchugina N. Yu.¹⁶^ORCID,Kushubakova N. A.³¹^ORCID,Levankova V. I.⁶⁷^ORCID,Lyubavina N. A.¹³^ORCID,Magdeyeva N. A.⁶^ORCID,Mazalov K. V.³⁸,Majseenko V. I.³⁰^ORCID,Makarova A. S.²⁸^ORCID,Maripov A. M.³¹^ORCID,Marusina A. A.⁵²^ORCID,Melnikov E. S.⁶⁸^ORCID,Moiseenko N. B.¹⁵^ORCID,Muradova F. N.¹³^ORCID,Muradyan R. G.⁶⁹,Musaelian Sh. N.³⁶,Myshak A. O.⁷⁰,Nekaeva E. S.¹³^ORCID,Nikitina N. M.⁶^ORCID,Ogurlieva B. B.⁷¹,Odegova A. A.²⁵^ORCID,Omarova Yu. M.¹³^ORCID,Omurzakova N. A.³¹^ORCID,Ospanova Sh. O.³²,Pahomova E. V.⁷²^ORCID,Petrov L. D.⁷³,Plastinina S. S.¹³^ORCID,Pogrebetskaya V. A.⁷⁴,Polyakov D. V.⁴⁰^ORCID,Polyakov D. S.¹³^ORCID,Ponomarenko E. V.⁷⁵,Popova L. L.¹⁶^ORCID,Prokofeva N. A.¹¹^ORCID,Pudova I. A.⁷⁶,Rakov N. A.¹³,Rakhimov A. N.²⁰,Rozanova N. A.¹⁸,Serikbolkyzy S.³²,Simonov A. A.¹¹^ORCID,Skachkova V. V.⁴⁵^ORCID,Soloveva D. V.¹⁵^ORCID,Soloveva I. A.⁷⁷^ORCID,Sukhomlinova I. M.⁷⁸,Sushilova A. G.¹¹^ORCID,Tagayeva D. R.²⁰,Titojkina Yu. V.¹²^ORCID,Tikhonova E. P.²⁶^ORCID,Tokmin D. S.⁷⁹,Tolmacheva A. A.⁸⁰^ORCID,Torgunakova M. S.²⁶^ORCID,Trenogina K. V.⁴⁵^ORCID,Trostianetckaia N. A.¹¹,Trofimov D. A.⁸¹^ORCID,Trubnikova M. A.⁸²^ORCID,Tulichev A. A.⁸³^ORCID,Tursunova A. T.³²,Ulanova N. D.⁸⁴^ORCID,Fatenkov O. V.¹⁶^ORCID,Fedorishina O. V.²⁸^ORCID,Fil T. S.¹¹^ORCID,Fomina I. Yu.⁸⁵,Fominova I. S.⁸⁶,Frolova I. A.³⁸,Tsvinger S. M.²³^ORCID,Tsoma V. V.⁵^ORCID,Cholponbaeva M. B.³¹,Chudinovskikh T. I.²⁵^ORCID,Shevchenko O. A.⁸⁷,Sheshina T. V.¹⁵,Shishkina E. A.³³^ORCID,Shishkov K. Yu.¹⁶^ORCID,Sherbakov S. Yu.⁸⁸,Yausheva E. A.⁸⁹

Affiliation:

1. Association "Eurasian Association of Therapists"; Pirogov Russian National Research Medical University

2. Association "Eurasian Association of Therapists"; Privolzhsky Research Medical University

3. The First Moscow state medical University I. M. Sechenov

4. "Almazov National Medical Research Centre” of the Ministry of Health of the Russian Federation

5. Volgograd State Medical University

6. Saratov State Medical University named after V.I. Razumovsky

7. "NMIC cardiology" of the Ministry of health of the Russian Federation

8. Rostov State Medical University

9. Erebouni Cardiology Center

10. Nicolae Testemitanu State University of Medicine and Pharmacy

11. North-Western State Medical University named after I.I. Mechnikov

12. Ogarev Mordovia State University

13. Privolzhsky Research Medical University

14. The Republican Center for Cardiovascular Diseases of State Autonomous Institution of Health "Interregional Clinical Diagnostic Center"; SBEI HPE "Kazan State Medical University"

15. National Research Lobachevsky State University of Nizhni Novgorod

16. Samara State Medical University

17. Krasnoyarsk state medical University named after Professor V. F. Voino-Yasenetsky; Regional state budgetary healthcare institution "Regional Clinical Hospital" (RSBHI RCH)

18. Krasnogorsk city hospital № 1

19. Kirovsk Interdisrict Hospital

20. The Republican Specialized Scientific and Practical Medical Center for Therapy and Medical Rehabilitation

21. Medical Center "GAUZ GKB №7"

22. Petrozavodsk State University

23. Chita State Medical Academy of Medicine

24. Privolzhsky Research Medical University; "Nizhny Novgorod Research Institute of Hygiene and Occupational Pathology" of Rospotrebnadzor

25. Kirov State Medical University

26. Krasnoyarsk State Medical University. prof. V.F. Voino-Yasenetsky

27. Privolzhsky Research Medical University; City Clinical Hospital №13 of Nizhniy Novgorod

28. Irkutsk State Medical Academy of Postgraduate Education

29. Moscow City Clinical Hospital №40; Pirogov Russian National Research Medical University

30. Educational Institution «Gomel State Medical University»

31. National Center of Cardiology and Internal Medicine named after prof. M. Mirrakhimov

32. Asfendiyarov Kazakh National Medical University

33. Perm State Medical University named after E.A. Vagner

34. South-Ural State Medical University

35. Kazakh University of Continuing Education; Clinical Infectious Diseases Hospital named after I. Zhekenovа

36. Yerevan State Medical University

37. Perm Regional Clinical Cardiological Dispensary

38. The Volga District Medical Centre, Federal Medical and Biological Agency of Russia

39. Association “Eurasian Association of Therapists”; Pirogov Russian National Research Medical University

40. Pirogov Russian National Research Medical University

41. Association “Eurasian Association of Therapists”; North-Western State Medical University named after I.I. Mechnikov

42. Clinical City Hospital №1, Kishinev City

43. FSBI “Polyclinic №1” of the Administrative Directorate of the President of the Russian Federation

44. Krasnoyarsk Regional Hospital

45. Perm Regional Clinical Hospital

46. State Budgetary Institution of Healthcare of the Samara Region "Chapaevskaya Central City Hospital"

47. North-Western State Medical University named after I. I. Mechnikov

48. Republic hospital n.a. V.A. Baranov

49. Association “Eurasian Association of Therapists”; Psychiatric clinical hostpital named after P. Gannushkin

50. City Clinical Hospital No.25

51. State Budgetary Medical Institution Republic of Karelia Hospital for Veterans

52. Kirovsk Interdistrict Hospital

53. Private Healthcare Institution "Clinical Hospital RZHD Meditsyna at Samara railway station"

54. Irkutsk regional clinical hospital of Conferred Order of Merit

55. Krasnoyarsk State Medical University named after prof. V.F. Voino-Yasenetsky

56. Moscow City Clinical Hospital №40

57. GAUZ GKB №7

58. Nizhniy Novgorod City Hospital №40

59. Moscow City State Outpatient Hospital №134; Pirogov Russian National Research Medical University

60. Municipal Autonomous Healthcare Institution of the Order of the Red Banner of Labour "City Clinical Hospital №1" of Chelyabinsk city

61. South-Ural State Medical University; Municipal Autonomous Healthcare Institution of the Order of the Red Banner of Labour "City Clinical Hospital №1", Chelyabinsk city

62. "City clinical hospital №5" of Nizhniy Novgorod

63. Association "Eurasian Association of Therapists"

64. Nizhniy Novgorod City Hospital №13

65. Gorodetskaya Central City Hospital of Nizhniy Novgorod Region

66. Republic hospital n.a. S.V. Katkov

67. Petrozavodsk City polyclinic No. 1

68. Association "Eurasian Association of Therapists"; North-Western State Medical University named after I. I. Mechnikov

69. Global Medical System clinics and hospitals

70. Group of companies "Medinvestgroup"

71. Pirogov Russian National Research Medical University; Moscow City Clinical Hospital #4

72. GBUZ RK "Republican tuberculosis dispensary"

73. Health Center of Briceni

74. SBHI of Nizhniy Novgorod Region "City Clinical Hospital #38"

75. Medical center «Zimamed»

76. Privolzhsky Research Medical University; Nizhniy Novgorod city Outpatient Hospital #4

77. Krasnoyarsk State Medical University. prof. V.F. Voino-Yasenetsky; Regional state budgetary healthcare institution "Regional Clinical Hospital" (RSBHI RCH)

78. Saint-Petersburg hospital for veterans

79. Labs of the Future

80. Novosibirsk State Medical University; SBHCI of Novosibirsk region "Clinical Polyclinic #27"

81. Kazan State Medical University; Medical Center "GAUZ GKB №7"

82. Association "Eurasian Association of Therapists"; LLC “Fresenius Medical Care Kuban”

83. Privolzhsky Research Medical University; SBHI of Nizhniy Novgorod region City Clinical Hospital #3

84. Nizhniy Novgorod City Hospital #13

85. Privolzhsky Research Medical University; SBHI of Nizhniy Novgorod region City Outpatient Hospital #1

86. Clinical Hospital #4 of Republic Mordovia

87. SBHI of Samara Region "Samara City Polyclinic #3"

88. Kazan State Medical Academy

89. Ruzaevka city RZHD-Medicine hospital

Abstract

Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery in the Eurasian region according to the AKTIV register. Material and methods.The AKTIV register was created at the initiative of the Eurasian Association of Therapists. The AKTIV register is divided into 2 parts: AKTIV 1 and AKTIV 2. The AKTIV 1 register currently includes 6300 patients, while in AKTIV 2 — 2770. Patients diagnosed with COVID-19 receiving in- and outpatient treatment have been anonymously included on the registry. The following 7 countries participated in the register: Russian Federation, Republic of Armenia, Republic of Belarus, Republic of Kazakhstan, Kyrgyz Republic, Republic of Moldova, Republic of Uzbekistan. This closed multicenter register with two nonoverlapping branches (in- and outpatient branch) provides 6 visits: 3 in-person visits during the acute period and 3 telephone calls after 3, 6, 12 months. Subject recruitment lasted from June 29, 2020 to October 29, 2020. Register will end on October 29, 2022. A total of 9 fragmentary analyzes of the registry data are planned. This fragment of the study presents the results of the post-hospitalization period in COVID-19 survivors after 3 and 6 months. Results. According to the AKTIV register, patients after COVID-19 are characterized by long-term persistent symptoms and frequent seeking for unscheduled medical care, including rehospitalizations. The most common causes of unplanned medical care are uncontrolled hypertension (HTN) and chronic coronary artery disease (CAD) and/or decompensated type 2 diabetes (T2D). During 3- and 6-month follow-up after hospitalization, 5,6% and 6,4% of patients were diagnosed with other diseases, which were more often presented by HTN, T2D, and CAD. The mortality rate of patients in the post-hospitalization period was 1,9% in the first 3 months and 0,2% for 4-6 months. The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure. Conclusion. According to the AKTIV register, the health status of patients after COVID-19 in a serious challenge for healthcare system, which requires planning adequate health system capacity to provide care to patients with COVID-19 in both acute and post-hospitalization period.

Publisher

Silicea - Poligraf, LLC

Subject

Cardiology and Cardiovascular Medicine

Reference23 articles.

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