THE ROLE OF SYSTEMIC INFLAMMATION IN DECREASE OF ELASTICITY OF MAGISTRAL ARTERIES AND  IN PROGRESSION OF ENDOTHELIAL DYSFUNCTION IN PATIENTS WITH SYSTEMIC HYPERTENSION,  ObESITY AND TYPE 2 DIAbETES

Author:

Statsenko M. E.1ORCID,Derevyanchenko M. V.1ORCID

Affiliation:

1. Volgograd State Medical University of the Ministry of Health.

Abstract

Aim. To evaluate the role of systemic inflammation in decrease of magistral arteries elasticity and progression of endothelial dysfunction in arterial hypertension (AH) patients comorbid with obesity and/or type 2 diabetes (DM2).Material and methods. Ninety patients with AH stages II-III, 45-65 year old, were selected to 3 groups. Group 1 — patients with “isolated” AH, group 2 — AH with obesity, group 3 — AH and DM2 patients. Standard physical examination was done, vascular stiffness assessment by pulse wave velocity (PWV) measurement of the vessels of muscular (PWVm) and elastic (PWVe) types; the levels were measured of systemic inflammation markers, endothelial dysfunction and fibrosis.Results. PWVe and PWVe >10 m/s were significantly more common in group 3 patients comparing to group 1 (10,3 [9,5;11,7] vs 9,0 [8,0;11,3] m/s and 70 vs 40%, respectively). Concentration of C-reactive protein (CRP) was significantly higher in AH with DM2 comparing to AH and obesity or only AH (7,92 [4,77;16,15] vs 4,77 [4,53;5,43], 7,92 [4,77;16,15] vs 2,98 [0,65;7,19] mg/L, respectively). Level of endothelin-1 (E1) in blood serum increased significantly in 1 to 3 group, with significant differences in all groups. In AH and DM2 patients, concentration of collagen type 4 in the blood was statistically significantly higher than in AH and obesity patients and only AH (5,67 [3,58;9,20] vs 2,94 [2,57;8,45], 5,67 [3,58;9,20] vs 2,63 [2,23;7,28] ng/mL). Correlational analysis showed the presence of highly significant correlations in concentrations of CRP and PWVe (r=0,41), level of E1 (0,51), in E1 and duration of DM2 anamnesis (r=0,58), body mass index (r=0,35), smoking (r=0,54), PWVm (r=0,47), PWVe (r=0,47), in concentration of collagen type 4 and duration of DM2 anamnesis (r=0,36), PWVe (r=0,31). Conclusion.  The data obtained witness on the negative influence of systemic inflammation on the elasticity of vascular wall of magistral arteries, and on its importance in progression of endothelial dysfunction in AH patients comorbid with obesity and DM2.

Publisher

Silicea - Poligraf, LLC

Subject

Cardiology and Cardiovascular Medicine

Reference16 articles.

1. 2013 ESH/ESC Guidelines for the management of arterial hypertension Eur Heart J 2013; 34: 2159-219. DOI:10.1093/eurheartj/eht151.

2. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 2010; 55: 1318-27. DOI: 10.1016/j.jacc.2009.10.061.

3. Van Bortel LM, Laurent S, Boutouyrie P, et al. Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens 2012; 30: 445-8. DOI: 10.1097/HJH.0b013e32834fa8b0.

4. Vasyuk YA, Galyavich AS, Ivanova SV, et al. Consensus of Russian experts to assess arterial stiffness in clinical practice, the Russian Society of Cardiology, 2015: draft. http://www. scardio.ru/rekomendacii/proekty_rekomendaciy/. (In Russ.) Vasyuk Yu. A., Galyavich A. S., Ivanova S. V. i dr. Soglasovannoe mnenie rossiiskikh ekspertov po otsenke arterial'noi zhestkosti v klinicheskoi praktike Rossiiskoe obshchestvo kardiologov, 2015: proekt. http://www.scardio.ru/rekomendacii/proekty_rekomendaciy/.

5. Statsenko ME, Derevyanchenko MV. The condition of large vessels and microcirculation is a new target of antihypertensive therapy in patients with arterial hypertension and type 2 diabetes mellitus. Ratsional’naya farmakoterapiya v kardiologii. 2016; 12 (1): 21-5. (In Russ.) Statsenko M. E., Derevyanchenko M. V. Sostoyanie krupnykh sosudov i mikrotsirkulyatsii — novaya mishen' antigipertenzivnoi terapii u bol'nykh arterial'noi gipertenziei i sakharnym diabetom 2 tipa. Ratsional'naya farmakoterapiya v kardiologii. 2016; 12 (1): 21-5. DOI:10.20996/1819-6446-2016-12-1-21-25

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