Analysis of data from the Russian AURA registry (real-world data registry on AlbUminuRia detection rate among patients with previously undiAgnosed chronic kidney disease)-Reference-Cited by-同舟云学术

Analysis of data from the Russian AURA registry (real-world data registry on AlbUminuRia detection rate among patients with previously undiAgnosed chronic kidney disease)

Published:2024-08-29 Issue:7 Volume:29 Page:5926
ISSN:2618-7620
Container-title:Russian Journal of Cardiology
language:
Short-container-title:Russ J Cardiol

Author:

Batyushin M. M.¹^ORCID,Trubnikova M. A.²^ORCID,Arutyunov G. P.³^ORCID,Tarlovskaya E. I.⁴^ORCID,Arutyunov A. G.⁵^ORCID,Polyakov D. S.⁶^ORCID,Akhmedkhanov S. Sh.⁷^ORCID,Bakulin I. G.⁸^ORCID,Bodrievskaya I. A.⁹^ORCID,Viktorova I. A.¹⁰^ORCID,Vinogradova N. G.¹¹^ORCID,Galyavich A. S.¹²^ORCID,Garganeeva N. P.¹³^ORCID,Grigorieva N. Yu.¹⁴^ORCID,Erofeeva S. B.¹⁵^ORCID,Kercheva M. A.¹⁶^ORCID,Kechedzhieva S. G.¹⁷^ORCID,Koryagina N. A.¹⁸^ORCID,Malchikova S. V.¹⁹^ORCID,Nevzorova V. A.²⁰^ORCID,Nedogoda S. V.²¹^ORCID,Petrova M. M.²²^ORCID,Pogrebetskaya V. A.²³^ORCID,Rebrov A. P.²⁴^ORCID,Rubanenko O. A.²⁵^ORCID,Safianik E. A.²⁶^ORCID,Skibitsky V. V.²⁷^ORCID,Smirnova E. A.²⁸^ORCID,Starovoitova E. A.¹³^ORCID,Khamitov R. F.²⁹^ORCID,Chesnikova A. I.¹^ORCID,Shabatina T. M.³⁰^ORCID,Shaposhnik I. I.³¹^ORCID,Vaisberg A. R.³²^ORCID,Aparkina A. V.²⁴^ORCID,Barykina I. N.²¹^ORCID,Batluk T. I.³³^ORCID,Bashkinov R. A.³⁴^ORCID,Beybalayeva A. T.⁷^ORCID,Belenikina Y. A.²⁸^ORCID,Bilevich O. A.¹⁰^ORCID,Bondareva Zh. V.²⁰^ORCID,Vaskin A. Yu.³³^ORCID,Vlasova T. V.³²,Galko E. V.³⁵^ORCID,Garifullin T. U.⁸^ORCID,Gordeychuk E. D.³^ORCID,Grigorieva E. V.²⁴^ORCID,Gubareva I. V.²⁵^ORCID,Danilova L. K.³⁶^ORCID,Dolgushina A. I.³¹^ORCID,Durygina E. M.³²^ORCID,Evdokimov D. S.⁸^ORCID,Zhdankina N. V.¹⁴^ORCID,Zheleznyak E. I.¹^ORCID,Zueva D. S.⁸^ORCID,Ivanova D. S.¹⁰^ORCID,Ivanchenko E. Yu.⁶^ORCID,Kazakovtseva M. V.¹⁹^ORCID,Kaznina A. A.³²^ORCID,Karoli N. A.²⁴^ORCID,Kaskaeva D. S.²²^ORCID,Kim Z. F.³⁷^ORCID,Kozlova M. V.³²^ORCID,Kudrinskaya Y. I.³¹^ORCID,Kuznetsova A. S.³¹^ORCID,Levchenko E. Yu.⁸^ORCID,Lukonin I. A.²⁷^ORCID,Lutova V. O.²¹^ORCID,Magdeeva N. A.²⁴^ORCID,Makarova E. V.³⁸^ORCID,Makarova N. E.³²^ORCID,Mamontova M. M.³⁹^ORCID,Melnikov E. S.³⁴^ORCID,Molostvova A. F.²⁹^ORCID,Naborshchikova T. D.⁸^ORCID,Nikitina I. N.²⁸^ORCID,Novikova D. P.⁴⁰^ORCID,Novikova M. V.⁴¹^ORCID,Pakusina V. I.³²^ORCID,Pereverzeva K. G.²⁸^ORCID,Pleshakov I. S.⁴²,Pokramovich Yu. G.¹⁵^ORCID,Ponomareva O. V.²⁸^ORCID,Popova E. A.²¹^ORCID,Popova N. A.³²^ORCID,Potapova E. S.²⁰^ORCID,Resnyanskaya E. D.⁸^ORCID,Rozhkova M. Yu.¹⁰^ORCID,Rubanenko A. O.²⁵^ORCID,Rudoy M. D.⁴³^ORCID,Salasyuk A. S.²¹^ORCID,Salimova L. M.²⁹^ORCID,Samokhina V. I.²⁸^ORCID,Sanginova N. Sh.³²^ORCID,Sattarova F. I.²⁹^ORCID,Safina A. Kh.⁴⁴^ORCID,Sirotenko D. P.⁴⁵^ORCID,Skarzhinskaya N. S.¹^ORCID,Skibitsky A. V.²⁷^ORCID,Suchkova E. I.²⁸^ORCID,Tepnadze L. E.²²^ORCID,Fendrikova A. V.²⁷^ORCID,Filatova T. E.²⁸^ORCID,Filyushin O. V.²⁸^ORCID,Chizhova O. Yu.⁸^ORCID,Chudinovskikh T. I.¹⁹^ORCID,Yakushin S. S.²⁸^ORCID,Yashina E. M.¹⁴^ORCID

Affiliation:

1. Rostov State Medical University

2. Eurasian Association of Internal Medicine; OOO Dr Fomin Clinic

3. Eurasian Association of Internal Medicine; Pirogov Russian National Research Medical University

4. Eurasian Association of Internal Medicine; Privolzhsky Research Medical University

5. Eurasian Association of Internal Medicine; Avdalbekyan National Institute of Health

6. Privolzhsky Research Medical University; Lobachevsky National Research State University of Nizhny Novgorod

7. Dagestan State Medical University

8. Mechnikov North-Western State Medical University

9. Russian Railways-Medicine Clinical Hospital

10. Omsk State Medical University

11. Privolzhsky Research Medical University; Lobachevsky National Research State University of Nizhny Novgorod; City Clinical Hospital № 38

12. Interregional Clinical Diagnostic Center; Kazan State Medical University

13. Siberian State Medical University

14. Lobachevsky National Research State University of Nizhny Novgorod

15. Vladimirsky Regional Research Clinical Institute

16. Cardiology Research Institute, Tomsk National Research Medical Center

17. Stavropol State Medical University

18. Vagner Perm State Medical University

19. Kirov State Medical University

20. Pacific State Medical University

21. Volgograd State Medical University

22. Voino-Yasenetsky Krasnoyarsk State Medical University

23. City Clinical Hospital № 38

24. Razumovsky Saratov State Medical University

25. Samara State Medical University

26. Ural State Medical University

27. Kuban State Medical University

28. Pavlov Ryazan State Medical University

29. Kazan State Medical University

30. Pirogov Russian National Research Medical University

31. South Ural State Medical University

32. Privolzhsky Research Medical University

33. Eurasian Association of Internal Medicine

34. Eurasian Association of Internal Medicine; Mechnikov North-Western State Medical University; Clinical Rheumatology Hospital № 25

35. Voino-Yasenetsky Krasnoyarsk State Medical University; Russian Railways-Medicine Regional Hospital Polyclinic № 1

36. Voino-Yasenetsky Krasnoyarsk State Medical University; Federal Siberian Research Clinical Center

37. Kazan State Medical University; City Clinical Hospital № 7

38. Privolzhsky Research Medical University; Nizhny Novgorod Research Institute of Hygiene and Occupational Diseases

39. Russian Railways-Medicine Regional Hospital Polyclinic № 1

40. Regional Clinical Hospital

41. Regional Clinical Cardiology Dispensary,

42. Samara City Clinic № 13

43. Nizhny Novgorod Research Institute of Hygiene and Occupational Diseases

44. City Clinical Hospital № 7

45. Regional Clinical Hospital; Omsk Region City Clinic № 1

Abstract

Aim. To present data from the AURA Registry (real-world data registry on AlbUminuRia detection rate among patients with previously undiAgnosed chronic kidney disease). It is important to perform population studies both to study the occurrence of markers (albuminuria (AU), decreased glomerular filtration rate (GFR)) and the prevalence of chronic kidney disease (CKD), which will provide information on the actual detection rate of CKD and the related markers in territories included in the registry of research centers.Material and methods. The article presents the first data from the AURA registry. Recruitment was carried out from March 6, 2023 to January 23, 2024. Thirty-four research centers in various federal districts of the Russian Federation and 104 doctors took part in the recruitment. We included 4580 subjects over the age of 40 years who had no previously established diagnosis of CKD and did not have type 1 or type 2 diabetes. During recruitment, the researchers were guided by the AURA study protocol (Version 1.7/12-26-2022).Results. AU more than 20 mg/g was detected in 64,9% of cases. At the same time, AU is more common at GFR values that may correspond to stage 3A of CKD. The rarer occurrence of AU in those examined with GFR >60 ml/min/1,73 m2 may be explained by less severe renal damage at this CKD stage. The incidence of AU was significantly higher in men, older people, smokers, people with metabolic syndrome, hypertension (HTN), prediabetes and overweight. The occurrence of AU also increased as HTN grade increased. AU detection rate was associated with hypertriglyceridemia, a high blood level of C-reactive protein, which is an integrative marker of inflammation that negatively affects cardiovascular risk.Conclusion. The presented first data from the AURA registry demonstrated the high AU prevalence in people over 40 years of age. A high incidence of AU was typical for patients with HTN, coronary artery disease, atrial fibrillation, heart failure, and prediabetes. An association has been demonstrated between the high incidence of AU and male sex, age, overweight, hyperuricemia, dyslipidemia, and a number of other cardiovascular risk factors.

Publisher

Silicea - Poligraf, LLC

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