Author:
Muhammad Mohiuddin Alamgir ,Jamal Qamar,Mirza Talat
Abstract
Objective: To determine the risk for oral cancer caused by simultaneous occurrence of more than one of the tested cytochrome P450 1A1MspI, glutathione S-transferaseM1 null gnd Glutathione S-transferasesT1 null gene polymorphisms.
Method: The cross-sectional case-control study was conducted from December 2011 to October 2016 at the Ziauddin University, Karachi, in collaboration with Dow University of Health Sciences, Karachi, and comprised oral squamous cell carcinoma cases in group A and healthy tobacco habit-matched controls in group B. All investigations were done using standardised laboratory protocols. The outcomes were determined in terms of association of various combinations of cytochrome P450 1A1MspI, glutathione S-transferasesM1 null and glutathione S-transferases T1 null polymorphisms with oral cancer. Data was analysed using SPSS 20.
Results: Of the 238 subjects, 140(58.8%) were in group A and 98(41.2%) were in group B. Mean ages in group A and B were 47.1±12.22 and 41.6±14.58 years, respectively. Male/Female ratio in group A was 1.88:1 while 83.4% were using tobacco. When cytochrome P450 1A1MspI homozygous (m2/m2) and glutathione S-transferasesM1 null variants occured simultaneously in an individual, an odds ratio of 12.8 (95% confidence interval: 1.20-135.5; p=0.03) among overall tobacco chewers was observed. For glutathione S-transferasesM1 not null and glutathione S-transferasesT1 null variant combination among overall tobacco users, the conferred odds ratio was 4.58 (95% confidence interval: 0.99-21.2; p=0.05). The other studied gene combinations did not reveal significant associations (p>0.05).
---Continue
Publisher
Pakistan Medical Association
Reference21 articles.
1. Omiecinski CJ, Heuve VJP, Perdew GH, Peters JM. Xenobiotic metabolism, disposition, and regulation by receptors:From biochemical phenomenon to predictors of major toxicities. Toxicol Sci.2011; 120:S49-75.
2. Gundert-RemyU, BernauerU, BlomekeB, DoringB, FabianE, GoebelC, etal. Extrahepatic metabolism at the body’s internal-external interfaces. Drug Metab Rev.2014; 46:291-324.
3. Taspinar M, Aydos SE, ComezO, Elban AH, Karabulut HG, Sunguroglu A. CYP1A1,GST gene polymorphisms and risk of chronic myeloid leukaemia.Swiss Med Wkly.2008; 138:12-7.
4. KatakwarP, MetqudR, NaikS, MittalR. Oxidative stress marker in oral cancer:A review. J Can Res Ther.2016; 12:438-46.
5. Peddireddy V, Badabagni SP, Gundimeda SD, Mamidipudi V, Penagaluru PR, Mundluru HP. Association of CYP1A1,GSTM1 and GSTT1 gene polymorphisms with risk of non-small cell lung cancer in Andhra Pradesh region of South India. [Online] [Cited 2021 Jan 13].Available from: URL:https://link.springer.com/article/10.1186/s40001-016-0209-x
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献