Author:
Baeva Elena S.,Artyukhov Elena S.,Kurkina Olga S.
Abstract
The effect of mexidol, doxycycline hydrochloride and sodium nitrite solutions on human oxyhemoglobin molecules was studied by spectrophotometry. It is shown that the presence of modifiers in the incubation medium in combination and separately contributes to their specific affinity to the hemoglobin molecule, which is reflected in the change in the ratio of ligand forms of hemoprotein. A tendency to decrease the level of methemoglobin formation in samples containing doxycycline and mexidol was revealed. Preliminary incubation of hemoglobin solutions with antibiotics studied helps to reduce the oxidative effect of sodium nitrite against hemoprotein molecules. The data obtained confirm the concept of the presence of non-antibacterial effects of doxycycline.
Publisher
Volgograd State Medical University