CARDIOVASCULAR EFFECTS OF CHEMIO- AND RADIATION THERAPY IN CANCER PATIENTS: WHAT A CARDIO-ONCOLOGIST SHOULD KNOW (PART I)

Abstract

The review presents an analysis of current literature data demonstrating the pathophysiological mechanisms of the development of cardiovascular complications of chemo- and radiation therapy in cancer patients. The undoubted successes achieved in the treatment of oncological diseases can improve survival and reduce mortality. However, there was a problem of increasing cardiovascular complications during long-term treatment, due to various toxic side effects of chemo- and radiation therapy from the cardiovascular system. For comprehensive prevention and treatment, as well as to improve the prognosis, it is necessary to understand the mechanisms and interactions of drugs underlying the interstitial curation of cancer patients. The purpose of this review is to analyze literature sources illustrating the pathophysiological mechanisms of cardiovascular toxicity in the appointment of chemotherapy and radiation therapy in clinical practice in cancer patients.