Intestinal adaptation in short bowel syndrome. What is new?

Abstract

Short bowel syndrome is the first cause of intestinal failure, which requires intravenous supplementation (hydro-electrolytic and/or caloric).  Physiological intestinal adaptation occurs 1 to 2 years after resection. This adaptation includes hyperphagia, changes in microbiota, morphological intestinal changes (including hyperplasia), hormonal adaptation... The colon plays a major role and permits hydro-electrolytic and energy recuperation. It is possible to enhance the physiologic adaptation by optimizing the dietary intervention, restoring the continuity and by giving a growth factor treatments such as GLP-2 analog(Glucagon-Like Peptide-2).