Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD

Author:

Rogers Kelly A.1,Moreno Sarah E.1,Smith Laurie A.1,Husson Hervé1,Bukanov Nikolay O.1,Ledbetter Steven R.1,Budman Yeva2,Lu Yuefeng3,Wang Bing2,Ibraghimov-Beskrovnaya Oxana1,Natoli Thomas A.1

Affiliation:

1. Department of Rare Renal Disease Research; Sanofi-Genzyme R&D Center; Framingham Massachusetts

2. Department of Analytical Research and Development; Sanofi Corporation; Waltham Massachusetts

3. Department of Biostatistics and Programming; Sanofi-Genzyme R&D Center; Framingham Massachusetts

Funder

Sanofi-Genzyme

Publisher

Wiley

Subject

Physiology (medical),Physiology

Reference78 articles.

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2. Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene;Boulter;Proc. Natl Acad. Sci. U. S. A.,2001

3. Long-lasting arrest of murine polycystic kidney disease with CDK inhibitor roscovitine;Bukanov;Nature,2006

4. Injury and development in polycystic kidney disease;Calvet;Curr. Opin. Nephrol. Hypertens.,1994

5. Role of lactosylceramide and MAP kinase in the proliferation of proximal tubular cells in human polycystic kidney disease;Chatterjee;J. Lipid Res.,1996

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