Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice-Reference-Cited by-同舟云学术

Treatment with didemnin B, an elongation factor 1A inhibitor, improves hepatic lipotoxicity in obese mice

Published:2016-09 Issue:17 Volume:4 Page:e12963
ISSN:2051-817X
Container-title:Physiological Reports
language:en
Short-container-title:Physiol Rep

Author:

Hetherington Alexandra M.¹,Sawyez Cynthia G.¹²³,Sutherland Brian G.²,Robson Debra L.¹,Arya Rigya¹,Kelly Karen⁴,Jacobs René L.⁴,Borradaile Nica M.¹

Affiliation:

1. Department of Physiology and Pharmacology; Schulich School of Medicine and Dentistry; Western University; London Ontario Canada

2. Robarts Research Institute; Schulich School of Medicine and Dentistry; Western University; London Ontario Canada

3. Department of Medicine; Schulich School of Medicine and Dentistry; Western University; London Ontario Canada

4. Metabolic and Cardiovascular Diseases Laboratory; Department of Agricultural, Food and Nutritional Science; University of Alberta; Edmonton Alberta Canada

Funder

Canadian Institutes of Health Research

Canadian Lipoprotein Conference

Publisher

Wiley

Subject

Physiology (medical),Physiology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.14814/phy2.12963/fullpdf

Reference41 articles.

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2. Fate of tritiated didemnin B in mice: excretion and tissue concentrations after an intraperitoneal dose;Beasley;Biopharm. Drug Dispos.,2005

3. A critical role for eukaryotic elongation factor 1A-1 in lipotoxic cell death;Borradaile;Mol. Biol. Cell,2006

4. A subset of dysregulated metabolic and survival genes is associated with severity of hepatic steatosis in obese Zucker rats;Buque;J. Lipid Res.,2010

5. Serum lipoprotein and apolipoprotein profiles of the genetically obese ob/ob mouse;Camus;Biochim. Biophys. Acta,1988

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