Activation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblasts-Reference-Cited by-同舟云学术

Activation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblasts

Published:2015-02 Issue:2 Volume:3 Page:e12295
ISSN:2051-817X
Container-title:Physiological Reports
language:en
Short-container-title:Physiol Rep

Author:

Asokananthan Nithiananthan¹²,Lan Rommel S.¹,Graham Peter T.¹,Bakker Anthony J.³,Tokanović Ana¹,Stewart Geoffrey A.¹

Affiliation:

1. School Pathology and Laboratory Medicine; University of Western Australia; 35 Stirling Highway Crawley Perth WA Australia

2. School of Psychology and Clinical Sciences; Charles Darwin University; Ellengowan Drive; Casuarina Darwin NT Australia

3. School of Anatomy, Physiology and Human Biology; University of Western Australia; 35 Stirling Highway Crawley Perth WA Australia

Funder

National Health and Medical Research Council (NH&MRC)

Healy Medical Research Foundation

Publisher

Wiley

Subject

Physiology (medical),Physiology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.14814/phy2.12295/fullpdf

Reference64 articles.

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2. Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells;Asokananthan;J. Immunol.,2002

3. Airway structural alterations selectively associated with severe asthma;Benayoun;Am. J. Respir. Crit. Care Med.,2003

4. Thrombin differentiates normal lung fibroblasts to a myofibroblast phenotype via the proteolytically activated receptor-1 and a protein kinase C-dependent pathway;Bogatkevich;J. Biol. Chem.,2001

5. Dabigatran, a direct thrombin inhibitor, demonstrates antifibrotic effects on lung fibroblasts;Bogatkevich;Arthritis Rheum.,2009

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