Mapping of the FGF14:Nav1.6 complex interface reveals FLPK as a functionally active peptide modulating excitability-Reference-Cited by-同舟云学术

Mapping of the FGF14:Nav1.6 complex interface reveals FLPK as a functionally active peptide modulating excitability

Published:2020-07 Issue:14 Volume:8 Page:
ISSN:2051-817X
Container-title:Physiological Reports
language:en
Short-container-title:Physiol Rep

Author:

Singh Aditya K.¹^ORCID,Wadsworth Paul A.¹²³^ORCID,Tapia Cynthia M.¹⁴,Aceto Giuseppe⁵⁶,Ali Syed R.¹^ORCID,Chen Haiying¹,D'Ascenzo Marcello⁵⁶,Zhou Jia¹⁷^ORCID,Laezza Fernanda¹⁷⁸^ORCID

Affiliation:

1. Department of Pharmacology & Toxicology University of Texas Medical Branch Galveston TX USA

2. M.D.‐Ph.D. Combined Degree Program University of Texas Medical Branch Galveston TX USA

3. Biochemistry and Molecular Biology Graduate Program University of Texas Medical Branch Galveston TX USA

4. NIEHS Environmental Toxicology Training Program University of Texas Medical Branch Galveston TX USA

5. Department of Neuroscience Università Cattolica del Sacro Cuore Rome Italy

6. Fondazione Policlinico Universitario A. Gemelli IRCCS Rome Italy

7. Center for Addiction Research University of Texas Medical Branch Galveston TX USA

8. Center for Neurodegenerative Diseases University of Texas Medical Branch Galveston TX USA

Funder

National Institutes of Health

National Institute of Mental Health

National Institute on Aging

Publisher

Wiley

Subject

Physiology (medical),Physiology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.14814/phy2.14505

Reference75 articles.

1. Functional Modulation of Voltage-Gated Sodium Channels by a FGF14-Based Peptidomimetic

2. Modulation of the FGF14:FGF14 Homodimer Interaction Through Short Peptide Fragments

3. Identification of Amino Acid Residues in Fibroblast Growth Factor 14 (FGF14) Required for Structure-Function Interactions with Voltage-gated Sodium Channel Nav1.6

4. Genetic deletion of fibroblast growth factor 14 recapitulates phenotypic alterations underlying cognitive impairment associated with schizophrenia

5. Stabilization of protein-protein interactions in drug discovery

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