Individualized treatment strategies for hyperuricemia informed by a semi-mechanistic exposure-response model of uric acid dynamics

Author:

Aksenov Sergey1ORCID,Peck Carl C.2,Eriksson Ulf G.3,Stanski Donald R.4

Affiliation:

1. Quantitative Clinical Pharmacology; Early Clinical Development; IMED Biotech Unit; AstraZeneca; Waltham MA

2. University of California at San Francisco and NDA Partners LLC; San Luis Obispo CA

3. Quantitative Clinical Pharmacology; Early Clinical Development; IMED Biotech Unit; AstraZeneca; Gothenburg Sweden

4. Quantitative Clinical Pharmacology; Early Clinical Development; IMED Biotech Unit; AstraZeneca; Gaithersburg MD

Publisher

Wiley

Subject

Physiology (medical),Physiology

Reference46 articles.

1. Renal Basis of Hyperuricemia

2. Definition of hyperuricemia and gouty conditions;Bardin;Curr. Opin. Rheumatol.,2014

3. Lesinurad in combination with allopurinol: a randomised, double-blind, placebo-controlled study in patients with gout with inadequate response to standard of care (the multinational CLEAR 2 study);Bardin;Ann. Rheum. Dis.,2017

4. Bhattaram , V. A. J. Gobburu 2017 Pharmacometrics Review, Clinical Pharmacology Biopharmaceutics Review, Uloric (Febuxostat) Tablets [Online] https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/021856s000TOC.cfm

5. Uric acid metabolism in normal subjects and in gouty patients by chromatographic measurement of 14C-uric acid in plasma and urine;Bianchi;Metabolism,1979

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