Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation

Author:

Santacruz Lucia12ORCID,Arciniegas Antonio Jose Luis3,Darrabie Marcus4,Mantilla Jose G.4,Baron Rebecca M.3,Bowles Dawn E.4,Mishra Rajashree4,Jacobs Danny O.56

Affiliation:

1. Department of Molecular Biology and Biochemistry; The University of Texas Medical Branch; Galveston Texas

2. Department of Natural Sciences; Bowie State University; Bowie Maryland

3. Department of Medicine; Pulmonary and Critical Care Division; Brigham and Women's Hospital; Harvard Medical School; Boston Massachusetts

4. Duke University Medical Center; Durham North Carolina

5. Department of Surgery; The University of Texas Medical Branch; Galveston Texas

6. Institute for Translational Sciences; University of Texas Medical Branch; Galveston Texas

Funder

Department of Surgery, Duke University Medical Center

University of Texas Medical Branch

Publisher

Wiley

Subject

Physiology (medical),Physiology

Reference47 articles.

1. Neuroprotection of creatine supplementation in neonatal rats with transient cerebral hypoxia-ischemia;Adcock;Dev. Neurosci.,2002

2. Exogenous creatine delays anoxic depolarization and protects from hypoxic damage: dose-effect relationship;Balestrino;Brain Res.,1999

3. Role of creatine and phosphocreatine in neuronal protection from anoxic and ischemic damage;Balestrino;Amino Acids,2002

4. AMP-activated protein kinase is essential for survival in chronic hypoxia;Borger;Biochem. Biophys. Res. Commun.,2008

5. Cardiac muscle tissue engineering: toward an in vitro model for electrophysiological studies;Bursac;Am. J. Physiol.,1999

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