Hypoxic peripheral chemoreflex stimulation‐dependent cardiorespiratory coupling is decreased in swimmer athletes

Author:

Andrade David C.1ORCID,Arce‐Álvarez Alexis2ORCID,Salazar‐Ardiles Camila13ORCID,Toledo Camilo4ORCID,Guerrero‐Henriquez Juan5ORCID,Alvarez Cristian6ORCID,Vasquez‐Muñoz Manuel7ORCID,Izquierdo Mikel3ORCID,Millet Gregoire P.8ORCID

Affiliation:

1. Exercise Applied Physiology Laboratory, Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento Biomedico, Facultad de Ciencias de la Salud Universidad de Antofagasta Antofagasta Chile

2. Escuela de Kinesiología, Facultad de Odontología y Ciencias de la Rehabilitación Universidad San Sebastián Santiago Chile

3. Navarrabiomed Hospital Universitario de Navarra (UHN), Universidad Pública de Navarra (UPNA), IdiSNA Pamplona Navarra Spain

4. Laboratory of Cardiorespiratory and Sleep Physiology. Institute of Physiology. Faculty of Medicine Universidad Austral de Chile Valdivia Chile

5. Centro de Investigación en Fisiología y Medicina de Altura (FIMEDALT), Departamento de Ciencias de la Rehabilitación y el Movimiento Humano, Facultad de Ciencias de la Salud Universidad de Antofagasta Antofagasta Chile

6. Exercise and Rehabilitation Sciences Institute, School of Physical Therapy, Faculty of Rehabilitation Sciences Universidad Andres Bello Santiago Chile

7. Dirección de Docencia de Especialidades Médicas, Dirección de Postgrado, Facultad de Medicina y Ciencias de la Salud Universidad Mayor Santiago Chile

8. Institute of Sport Sciences University of Lausanne Lausanne Switzerland

Abstract

AbstractSwimmer athletes showed a decreased ventilatory response and reduced sympathetic activation during peripheral hypoxic chemoreflex stimulation. Based on these observations, we hypothesized that swimmers develop a diminished cardiorespiratory coupling due to their decreased hypoxic peripheral response. To resolve this hypothesis, we conducted a study using coherence time‐varying analysis to assess the cardiorespiratory coupling in swimmer athletes. We recruited 12 trained swimmers and 12 control subjects for our research. We employed wavelet time‐varying spectral coherence analysis to examine the relationship between the respiratory frequency (Rf) and the heart rate (HR) time series during normoxia and acute chemoreflex activation induced by five consecutive inhalations of 100% N2. Comparing swimmers to control subjects, we observed a significant reduction in the hypoxic ventilatory responses to N2 in swimmers (0.012 ± 0.001 vs. 0.015 ± 0.001 ΔVE/ΔVO2, and 0.365 ± 0.266 vs. 1.430 ± 0.961 ΔVE/ΔVCO2/ΔSpO2, both p < 0.001, swimmers vs. control, respectively). Furthermore, the coherence at the LF cutoff during hypoxia was significantly lower in swimmers compared to control subjects (20.118 ± 3.502 vs. 24.935 ± 3.832 area under curve [AUC], p < 0.012, respectively). Our findings strongly indicate that due to their diminished chemoreflex control, swimmers exhibited a substantial decrease in cardiorespiratory coupling during hypoxic stimulation.

Publisher

Wiley

Subject

Physiology (medical),Physiology

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