CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF METABOLITES OF THE GENUS ALHAGI

Abstract

In the review summarized the scientific literature on geographical distribution, the degree of knowledge of the chemical composition and biological activity of extracts and isolated individual compounds of the genus Alhagi Tourn. ex Adans. of the world flora. The structures of the isolated 300 compounds are presented belonging to the alkaloids, terpenoids, carbohydrates, hydrocarbons, lipids, and phenolic compounds. In quantitative terms, the phenolic compounds dominate, among which flavonoids belonging to the group flavone, flavonol, flavanone, isoflavone, isoflavonolignan and flavan-3-ols groups are prevails. Among them, to the chemotoxonomic markers can be include flavonols narcissin and its aglycone isorhamnetin, which are produced in major quantities in practically all species of the genus Alhagi. It was revealed that the qualitative composition of the metabolites of the same species of this genus depends on the ecological-geographical and soil-climatic conditions of their growth place. The data on the biological activity of extracts and isolated individual metabolites are considered. The main biologically active substances of the genus Alhagi are phenolic compounds. The presented information in the review shows that the plants of the genus Alhagi are promising for the creation of new pharmaceuticals. It was noted that in present time are being conducted in-depth preclinical pharmacological studies of the antioxidant preparation "Yantacin", the anti-inflammatory "Alkakhin", the biologically active complex "Alkhidin", and the antioxidant and antibacterial preparation "Zhantharid". Cited in the review information may be used as reference literature by phytochemists, biologists, and pharmacologists.