PERSPECTIVES OF WOOD-GREENERY BIOTECHNOLOGY ENRICHMENT WITH L-ARGININE AND INHIBITORS OF ITS CATABOLISM

Abstract

A promising source of L-arginine, as well as natural inhibitors of its catabolism enzymes, are plants. Free amino acids constitute a significant part of the water-soluble fraction of woody greenery of coniferous plants, including L-arginine. The biotechnology of L-arginine enrichment of coniferous woody greenery is developed by regulating nitrogen and boron support. The fact of a multiple increase in the pool of free L-arginine in needles suggests an increase in the level of enzyme inhibitors of its catabolism. Coniferous greens contain guanidine compounds, which are therapeutic agents for controlling the activity of nitric oxide synthases. L-arginine, one of the most universal amino acids in the metabolism of the animal body, in mammals is classified as a conditionally essential amino acid. The imbalance of the activities of the arginic and NO-synthase catabolism pathways of arginine, competing for the substrate, can lead to pathological consequences for the organism. Activation of inducible NO synthase or arginase reflects the type of inflammatory response in the development of specific diseases. In their treatment, the effectors controlling the activity of catabolism enzymes are considered as targets for pharmacological action. Examples of the use in folk medicine of extracts from some species of gymnosperms are given in the works of ethnomedical orientation. Analysis of the current state of studies of the metabolism of L-arginine in living organisms and its features in coniferous plants was carried out for the scientific substantiation of the prospects of obtaining enzymes for its metabolism of woody greens enriched with L-arginine and effector enzymes.