BIOSYNTHESIS, CHARACTERIZATION, ANTIMICROBIAL AND ANTICANCER PROPERTIES OF SILVER AND IRON NANOPARTICLES FROM ROSA CANINA L. EXTRACT

Abstract

The goal of this research was to make Ag and Fe nanoparticles out of Rosa canina (RC) fruit extract and test their anticancer and antibacterial activity against human breast cancer cell line and different human pathogenic bacteria. Green synthesis used to synthesize silver (RC-AgNPs) and iron (RC-FeNPs) nanoparticles from the fruit aqueous extract of RC. The formation of nanoparticles was characterized by scanning electron microscopy with energy dispersive x-ray spectroscopy, UV-Vis and Fourier transform infrared (FTIR) spectroscopy. RC-AgNPs formation was also investigated the surface charge, particle size, and distribution using zetasizer analysis by DLS. Both nanoparticles showed different levels of cytotoxicity against AGS (human gastric adenocarcinoma) cell line, while RC-AgNPs was not cytotoxic to HUVEC (Human umbilical vein endothelial) cell line in same concentrations which expressing selective anticancer effect. RC-AgNPs showed antibacterial activity against multidrug pathogens, but RC-FeNPs failed to show such activity. The current study's findings point to the prospective applications of green synthesized RC-AgNPs and RC-FeNPs in the biomedical, pharmaceutical, and nanotechnology industries.