Author:
Yuldashev Khabibulla Abdurasulevich,Esanov Rakhmat Sulton ugli,Uzbekov Vyacheslav Vadimovich,Saydullaeva Khulkar Tukhtamish kizi,Gafurov Makhmudzhan Bakiyevich,Oshchepkova Yuliya Igorevna,Salikhov Shavkat Ismailovich
Abstract
The problem of effective and safe therapy of cardiac arrhythmias requires the creation of new antiarrhythmic drugs with low toxicity. Clathration of medicinal substances with cyclodextrins or plant glycosides is a promising method for reducing their side effects and increasing their solubility.
The aim of this research is the complex formation of ethacizin hydrochloride with triterpene glycosides and the study of physicochemical properties of the resulting complexes.
Complexes of glycyrrhizic acid (GA) and its monoammonium salt (MASGA) with ethacizine hydrochloride (EtHQ) in various molar ratios (2 : 1, 4 : 1, 8 : 1) characterized by certain physicochemical parameters have been obtained. The resulting inclusion compounds were studied by UV and IR spectroscopy. It has been determined that molecular complexes of GA and MASGA with EtHQ are formed through weak intermolecular interactions, such as hydrogen bonding, electrostatic and hydrophobic interactions. Supramolecular complexes of natural glycosides with EtHQ have the same stoichiometric composition, approximately equal to the stability constant, and the negative value of the Gibbs free energy confirms the formation of a molecular complex as a result of autoassociation.
The obtained experimental data can serve and/or supplement scientific data for the creation of new promising drugs with a broad therapeutic effect, targeted delivery, synergistic effect and low toxicity.
Subject
Organic Chemistry,Plant Science,Biomaterials
Reference30 articles.
1. Conen D., Adam M., Roche F., Barthelemy J.C. et al. Circulation, 2012, vol. 126, pp. 2302–2308. DOI: 10.1161/CIRCULATIONAHA.112.112300.
2. Zatonskaya Ye.V., Matyushin G.V., Gogolashvvili N.G., Novgoroldtseva N.Ya. Sibirskoye meditsinskoye obozreniye, 2016, no. 3, pp. 5–16. (in Russ.).
3. Pelinovskaya L.I., Demko I.V., Mandrikova O.M., Glizer R.N. Sibirskoye meditsinskoye obozreniye, 2013, no. 4, pp. 60–62. (in Russ.).
4. Murakoshi N., Aonuma K. Circ. J., 2013, vol. 77, pр. 2419–2431. DOI: 10.1253/circj.cj-13-1129.
5. Zatonskaya Ye.V., Matyushin G.V., Gogolashvili N.G. Ratsional'naya farmakoterapiya v kardiologii, 2017, no. 13(3), pp. 403–408. (in Russ.).