PHYTOECDYSTEROIDS OF SERRATULA L. AND KLASEA CASS. GENERA: CHEMODIVERSITY, METHODS OF ISOLATION AND ANALYSIS

Abstract

Serratula L. and Klasea Cass. are two systematically related genera of Asteraceae family containing phytoecdysteroids, a group of natural terpene compounds with various biological activity. Beginning from the 1970s, 76 phytoecdysteroids were isolated and identified in 13 species of Serratula and 5 species of Klasea. This review presented information on the chemodiversity of phytoecdysteroids of Serratula and Klasea genera and their occurrence in individual species. It was shown that the structural features of Serratula and Klasea phytoecdysteroids include the presence of a complete side chain at C-20 atom as well as 5 to 7 hydroxyl groups. Among the species studied, the most investigated were S. coronata, S. tinctoria and S. chinensis with 50, 21 and 19 known compounds, respectively. Also in the review the information on the methods of extraction, isolation and analysis of phytoecdysteroids of the Serratula and Klasea genera was included. The special attention was paid to the data on chromatographic separation of phytoecdysteroids using column, thin-layer and high-performance liquid chromatography on the various sorbents. The information presented in the review demonstrated the perspectiveness of Serratula and Klasea species as sources of phytoecdysteroids.