AERIAL PART FERULA TENUISECTA ALTERNATIVE INDUSTRIAL RAW MATERIAL FOR THE PRODUCTION OF TEFESTROL SUBSTANCE

Abstract

The main losses of tefestrol have been identified and the advantages and disadvantages of the existing technology in the production of the substance from the aerial parts of Ferula tenuisecta have been established. It was found that the final product obtained by the existing technology has a green color that does not meet the requirements of the Pharmacopoeia article. The stage proposed of extraction of the sum of esters of sesquiterpene alcohols from the aerial part of Ferula tenuisecta and purification of the obtained extract, allowing to subsequent obtain the substance of tefestrol without green color. It has been shown that the use of activated carbon makes it possible to remove the green color of the extract. To purify tefestrol from other esters of sesquiterpene alcohols and accompanying substances, a chromatographic separation on silica gel is proposed under the following conditions: the ratio of the amount introduced into the column and the sorbent is 1 : 20; the ratio of the height of the sorption layer to the column diameter is 4 : 1; elution rate 35 l/h.m2. To obtain the pharmacopoeial substance of tefestrol is proposed, crystallization of a technical product from a mixture of ethyl acetate with hexane in a volume ratio of 1 : 3. Based on the results obtained, technology has been developed for obtaining the tefestrol substance from the aerial part of Ferula tenuisecta. Using this technology 70.96% of the substance of tefestrol is obtained from the content in the raw material, according to the existing technology 33.9%.