ADMINISTRATION OF OCHRATOXIN A TO LABORATORY ANIMALS AND ITS EFFECTS ON BLOOD PARAMETERS

Abstract

Mycotoxins are agents with different and complex chemical structures, with toxic effects for humans and animals. They can be present in feed and food, although in very small quantities, mycotoxins have a negative effect on the health of animals and people. Ochratoxins are mycotoxins intensively studied in recent years due to their toxicity on the animal and human body; these toxins show nephrotoxic, immunotoxic and myelotoxic, neurotoxic and carcinogenic effects. Thirty male rats of the Sprague- Dawley breed were divided into 3 groups who received through feed doses of of ochratoxin A (OTA): 0.5 mg OTA/kg BW, 1 mg OTA/kg BW and non OTA (control group). The blood samples collected on the anticoagulant were subjected to the analysis of the main components: hemoleucogram and biochemical parameters. The variations of the determined biochemical parameters (alanine aminotransferase, aspartat aminotransferase, serum creatinin, serum urea and blood urea nitrogen) indicate changes in the kidney and liver function in the animals from the experimental groups compared to the control group. The parameters of the hemoleucogram count also register variations depending on the administered dose of OTA.