POWER OF NANOPORE ANALYSIS FOR SUSTAINABLE AND EFFICIENT DIAGNOSTICS

Abstract

Nanopore technology has become widely used because of its ability to analyze molecules at an individual level, so we are seeing a dynamic development in the use of nanopores to analyze biological molecules. In 2014, the first commercial nanopore-based device capable of sequencing long strands of DNA or RNA. While the system appears to be working well, signal analysis still has barriers. The main advantage of nanopore sequencing is that it can study the structure of a single molecule and generate reads many times longer than genotyping methods. The nanopore analysis technique is low-energy and consumables are minimal, as samples in the order of tens of microliters are used, significantly reducing reagent requirements compared to traditional methods. In addition, the technique is targeted at the single molecule level, which can make it an accurate diagnostic method. Another advantage of nanopore analysis is its portability and the variety of samples that can be analyzed, making it a versatile technique for different areas of research. Using nanopores as a diagnostic tool can provide rapid diagnosis at the point of patient care without requiring significant material resources. This method is also environmentally sustainable, as it uses low levels of electricity and material waste, and could help reduce medical laboratories' environmental impact. Clinical laboratories are a factor that negatively impacts the planet's ecology, using equipment with a significant amount of electricity, chemical reagents, and disposable containers. Approaches to solving the problems are minimal, probably because it is difficult to do without certain facilities when it comes to health. We aim to highlight the importance of reducing energy and consumables consumption in medical laboratories by introducing an innovative solution, the nanopore analysis technique which has multiple benefits in terms of both medical and energy efficiency.