SIX-MEMBERED HETEROCYCLIC SULFONAMIDES: SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL PROPERTIES-Reference-Cited by-同舟云学术

SIX-MEMBERED HETEROCYCLIC SULFONAMIDES: SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL PROPERTIES

Published:2023-12-15 Issue: Volume:23 Page:369-375
ISSN:1314-2704
Container-title:SGEM International Multidisciplinary Scientific GeoConference� EXPO Proceedings
language:
Short-container-title:

Author:

Diaconu Dumitrela¹,Mangalagiu Violeta²,Amariucai-Mantu Dorina³,Antoci Vasilichia³,Mangalagiu Ionel⁴

Affiliation:

1. Alexandru Ioan Cuza University of Iasi, Institute of Interdisciplinary Research � CERNESIM Center, Alexandru Ioan Cuza University of Iasi, RECENT-AIR

2. Alexandru Ioan Cuza University of Iasi, Institute of Interdisciplinary Research � CERNESIM Center

3. Alexandru Ioan Cuza University of Iasi, Faculty of Chemistry

4. Alexandru Ioan Cuza University of Iasi, Institute of Interdisciplinary Research � CERNESIM Center, Alexandru Ioan Cuza University of Iasi, Faculty of Chemistry

Abstract

Sulfonamides are appropriate ligands for the preparation of coordination compounds with biological activity, as they possess bactericidal, antiviral, antidiabetic, and diuretic properties and some sulfonamide compounds are under clinical evaluation for cancer treatment. Metal complexes provide highly versatile platforms for drug design. Considering the biological potential of the quinoline nucleus, but also of the sulfonamide scaffold (especially antimicrobial), as well as that of the quinoline- sulfonamide combination we have decided to combine the two pharmacophore fragments. And at last, the complexation with divalent metals - M2+ (M2+: Zn2+, Cu2+, Co2+ and Cd2+) will bring complementary biological activity given by the cation with the final goal of achieving improved biological activity and better pharmacokinetic properties. The synthesized molecules were characterized by HRMS and NMR spectroscopy. The compounds were preliminary screened for their antibacterial and antifungal activity and the obtained results are very promising.v

Publisher

STEF92 Technology

Reference13 articles.

1. [1] Pozharskii, A.F., Soldatenkov, A., Heterocycles in Life and Society-AnIntroduction to Heterocyclic Chemistry, Biochemistry and Applications, Wiley,2011.

2. [2] Rocco F., The Miraculous Fever-Tree. The Cure that Changed the World, BritishMedical Journal, 327(7407), 649, 2003.

3. [3] Diaconu, D., Antoci, V., Mangalagiu, V., Amariucai-Mantu, D., Mangalagiu, I.I.Quinoline - imidazole/benzimidazole derivatives as dual- / multi- targeting hybridsinhibitors with anticancer and antimicrobial activity. Scientific Reports 12, 16988,2022.

4. [4] Antoci, V.; Cucu, D.; Zbancioc, Ghe.; Moldoveanu, C.; Mangalagiu, V.Amariucai-Mantu, D.; Aricu, A.; Mangalagiu, I.I. Bis-(imidazole/benzimidazole)-pyridine derivatives: synthesis, structure and antimycobacterial activity. Part XII,Future Medicinal Chemistry 12(3), 207-222, 2020.

5. [5] Popovici, L.; Amarandei, R.M.; Mangalagiu I.I.; Mangalagiu, V.; Danac, R.:Synthesis, molecular modelling and anticancer evaluation of new pyrrolo [1,2-b]pyridazine and pyrrolo [2,1-a]phthalazine derivatives, Journal Of EnzymeInhibition And Medicinal Chemistry, 34(1), 230-243, 2019.