The Opportunities for developing a new biologically active suture material in surgery (literature review)

Abstract

The main method of joining the wound edges in surgery remains suturing with the help of threads. Unfortunately, suture materials used in surgery have a number of disadvantages. The percentage of postoperative wound complications remains high. One of these consequences is the failure of the seam, depending also on the material used in the operation. Suture material, as a genetically alien object, that is a foreign body, with a long stay in the tissues can lead to the development of complications: causes suppuration of wounds, formation of abscesses, peritonitis. Materials and methods: The analysis of modern Russian-language and foreign literature, also Internet sources devoted to the issue of issues and modern developments of antiseptic suture material. As a result, the choice and development of an ideal suture material that meets all the requirements, remains an unsolved and socially significant problem in surgery. Despite the variety of variations already offered, there is currently no suture material with antimicrobial activity on the market that would fully reduce the risk of developing infections in the surgical area. But the achievements of modern chemical production make it possible to develop biologically active suture materials that have the ability to resist the development of infectious complications in a wound and improve tissue regeneration without adversely affecting the body. In addition, the analysis showed an increased interest of developers to chitosan, due to its exceptional biocompatibility, bioresorbability, non-toxicity, antibacterial properties and hemostaticity.