Effect of Deproteinized Dialysate from Vealers’ Blood on the Collagenogenesis in the Area of Polypropylene Hernioendoprosthesis ​​Implantation: аn Experimental Study

Abstract

Introduction. The choice of the optimal type of hernia endoprosthesis, as well as introduction of drugs with a collagen-forming effect into clinical practice, will improve the quality of treatment in patients with ventral hernias due to the formation of the full-fledged connective tissue both in the area of ​​the postoperative scar and in the area of ​​the hernia endoprosthesis placement. The aim of the study was to identify the effect of deproteinized dialysate from vealers blood on neocollagenesis in the area of endoprosthetics.Materials and methods. The experimental study included 80 laboratory white mice, Wistar line. All animals were divided into two groups (control and experimental). A polypropylene hernioendoprosthesis was implanted in animals of both groups. The division into groups was due to the use of deproteinized dialysate from the vealers blood.Results. The use of a polypropylene hernioendoprosthesis for abdominal wall plasty combined with the use of deproteinized dialysate created the necessary conditions for accelerating the processes of proliferation and maturation of fibroblastic cells.Conclusion. The maximum value of the ratio of collagen fibers of types I and III was achieved on the 90th day of the study, the difference between the value of this parameter was 1.24 times greater in the group of animals where deproteinized dialysate was used.