Author:
Ippolitova Lyudmila Ivanovna,Korotaeva Natalia Vladimirovna,Pershina Elena Sergeevna,Panichev Konstantin Vladimirovich,Lobanova Olga Alekseevna,Dilbaryan Artem Aleksandrovich
Abstract
Administration of surfactant by minimally invasive techniques that promote spontaneous breathing may be safer and more effective than administration with endotracheal intubation and mechanical ventilation. At present, the use of INSURE and LISA/MIST methods is well researched and widely used, their effectiveness has been largely proven and beyond doubt. However, current trends towards greater use of non-invasive respiratory support in surfactant-deficient preterm infants have created a demand for similar non-invasive methods of administering exogenous surfactant, one of which is the potentially promising method of inhaled delivery of a substance to the lungs using a nebulizer.
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