SAFETY OF HYPOGLYCEMIC THERAPY IN CASES OF PATIENTS WITH POLYMORBID PATHOLOGIES

Abstract

Impairment of the excretory function of the kidneys was revealed in 69% of patients with type 2 diabetes admitted to the hospital in therapeutic departments. A decrease of GFR below 30 ml/min/1,73 m2, which can significantly affect the choice and dosage regimen of hypoglycemic drugs, was recorded in 35% of patients. According to the anamnesis, sulfonylurea derivatives took 66.3% of hospitalized patients, biguanides in monotherapy - 25%, a combination of drugs from these two groups was prescribed in 35% cases. According to the analysis of the pharmacotherapy, 8.2% of patients with type 2 diabetes mellitus required correction of hypoglycemic therapy because of the functional state of the kidneys. According to the results of laboratory research methods , during hospitalization 3% of patients had episodes of hypoglycemia ( blood glucose level 3.9 mmol/L) or boundary values of glucose (blood glucose level = 4.0-4.1 mmol/L), but endocrinologist consultations and drug therapy correction hadn't been carried out. Therefore the lack of care of 'non-endocrinologists' regarding the risk of hypoglycemia in patients with type 2 diabetes with renal dysfunction leads to the absence of pharmacotherapy correction during hospitalization.