Optimization of rhbmp-2 active form production in a heterologous expression system using microbiological and molecular genetic approaches
Author:
Publisher
Media Sphere Publishing Group
Subject
General Medicine
Reference19 articles.
1. Zaytsev VV, Karyagina AS, Lunin VG. Bone morphogenetic proteins (BMPs): general characteristics, prospects of clinical application in traumatology and orthopedics. 2009;4:7984. (in Russian)
2. doi:10.1006/jmbi.1999.2590
3. Sharapova NE, Kotnova AP, Galushkina ZM, Lavrova NV, Poletaeva NN, Tukhvatulin AE et al. Production of the recombinant human bone morphogenetic protein-2 in Escherichia coli and testing of its biological activity in vitro and in vivo. Mol. biol. 2010;44(6):1036-44. (in Russian)
4. Osteoinductive capacity and heat stability of recombinant human bone morphogenetic protein-2 produced by Escherichia coli and dimerized by biochemical processing
5. Bone induction by Escherichia coli -derived recombinant human bone morphogenetic protein-2 compared with Chinese hamster ovary cell-derived recombinant human bone morphogenetic protein-2
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