Comparative analysis of genetic variants of the HIV-1 circulating in the Irkutsk region in 1999 and 2012-Reference-Cited by-同舟云学术

Comparative analysis of genetic variants of the HIV-1 circulating in the Irkutsk region in 1999 and 2012

Published:2016-06-28 Issue:3 Volume:61 Page:112-118
ISSN:2411-2097
Container-title:Problems of Virology
language:
Short-container-title:Problems of Virology

Author:

Lebedev A. V.^ORCID,Neshumaev D. A.^ORCID,Kazennova E. V.^ORCID,Lapovok I. A.^ORCID,Laga V. Yu.^ORCID,Tumanov A. S.^ORCID,Glushchenko N. V.^ORCID,Plotnikova Yu. K.^ORCID,Ponomareva O. A.^ORCID,Yarygina E. I.^ORCID,Bobkova M. R.^ORCID

Abstract

The pol and env genome regions of the HIV-1 genetic variants circulating in the irkutsk region of russia in 1999 and 2012 were compared. The results of this work showed the dominance of the HIV-1 subtype a IDU-A genetic variant (100%) in this region. No primary resistance mutations in the pol gene in the treatment-naive patients were found. The heterogeneity of the viral population was found to be significantly increased based on the pol and env analysis among HIV-variants isolated in 2012 (12.88% and 2.16%) from the intravenous drug users as compared to HIV-variants that caused the outbreak of the HIV infection in 1999 (1.64% and 0.47%). In addition, the comparison of genetic distances of the pol and env gene sequences in the viruses isolated in 2012 from the HIV-positive persons infected through heterosexual intercourse and intravenous drug use demonstrated that the transmission route influenced the variability of the virus population. Among the viruses of IDU-A variant circulating in the area in 2012 the prevalence of X4-tropic variants was 24.7%.

Publisher

Central Research Institute for Epidemiology

Subject

Infectious Diseases,Virology,General Medicine

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