THE STATE OF MICROCIRCULATION IN PATIENTS WITH VIBRATION DISEASE PROVIDING METABOLIC DISORDERS

Abstract

Introduction. It is known that the work experience under the influence of vibration correlates with the incidence of metabolic syndrome (MS) and type 2 diabetes mellitus (DM). Purpose: to study the state of microcirculation in vibration disease (VD) associated with the combined effects of local and general vibration complicated by DM or MS. Material and methods. A prospective cross-examination of the 38 VD men with I and II degree in combination with MS (group I) or DM (group II) study was conducted. The research of microcirculation indices was carried out on the laser analyzer “LAKK-01” on the skin of the second finger. Normalized values of the amplitudes of microcirculation oscillations, respectively, associated with endothelial (Ae/SD), neurogenic (An/SD), and myogenic (Am/SD) regulation of microvessels were determined. A comparison of quantitative indices was carried out using the Mann-Whitney test, the investigation of the relationship between signs - using Spearman correlation. Results. A statistically significant increase in An/SD was found in patients of group I. The decrease in Ae/SD in group II by 29.6% compared to the first group was at the level of p=0.05. The median Am/SD in both groups exceeded the upper reference level. Spastic type of microcirculation in VD+DM persons with was by 3 times more often, hyperemic - 1.68 times less often than in BD+MS, in 8% of cases there was a stagnant type microcirculation. 90% of all surveyed cases had venous stagnation. In patients with BD and MS, the type of microcirculation was in association with An/SD, an increase in Am/SD with a decrease Ae/SD. In persons with BD + DM Ae/SD is associated with the level of blood oxygen saturation and oxygen tissue consumption, the blood flow capillary reserve is associated with Am/SD. Conclusion. Microcirculation in BD+MS patients is characterized by partial safety of mutual regulatory influences between endothelial and myogenic modulations, decreased vascular tone due to myogenic and neurogenic mechanisms, the development of the hyperemic type. In patients with VD+DM polymorphic disorder of all types of modulations, an absence of mutually regulating associations between them, development of hyperemic, spastic and stagnant types was registered.