HYGENIC ASSESSMENT OF DYNAMICS OF CHLOROFORM EXPOSITION IN PERM REGION AND IT'S IMPACT ON CAUSING DISEASES OF THE BLOOD, BLOOD-FORMING ORGANS AND CERTAIN DISORDERS INVOLVING IMMUNE MECHANISM AMONG CHILDREN-Reference-Cited by-同舟云学术

HYGENIC ASSESSMENT OF DYNAMICS OF CHLOROFORM EXPOSITION IN PERM REGION AND IT'S IMPACT ON CAUSING DISEASES OF THE BLOOD, BLOOD-FORMING ORGANS AND CERTAIN DISORDERS INVOLVING IMMUNE MECHANISM AMONG CHILDREN

Published:2018-01-15 Issue:1 Volume:97 Page:29-34
ISSN:2412-0650
Container-title:Hygiene and sanitation
language:
Short-container-title:HAS

Author:

Chetverkina Kristina V.¹,Kleyn S. V.¹,Chigvintsev V. M.¹

Affiliation:

1. Federal Scientific Center for Medical and Preventive Health Risk Management Technologies

Abstract

On the basis of the system review, the relevance of the problem of the chloroform content in the drinking water of centralized drinking-water supply systems in the Perm Territory is confirmed. The comparative characteristic with the average Russian indices is presented. Insufficient volume of information containing data on the impact of the oral intake of chloroform on the blood system was established. There are presented results of the research content of chloroform in water samples from centralized drinking water supply in the cities of Perm region, as well as in the blood of the child population aged from 3 to 13 years living in these areas and consuming water under investigation in the period from 2011 to 2015. A long-term dynamics of the content of chloroform, contained in samples of drinking water and in bio-environments is described. A mathematical simulation of the dependence of the chloroform content in the blood as an exposure marker on the concentration of chloroform in water was carried out. As a result of the analysis of the prevalence rate of diseases of the blood system, hematopoietic organs and certain disorders involving the immune mechanism in the child population, there was established the relevance of differences between the territories of Permsky Krai with surface and underground water supply. The dynamics of the chloroform content in water and morbidity according to the class of blood diseases, hematopoietic organs and certain disorders involving the immune mechanism is presented and described. The association between the exposure to the oral intake of chloroform with drinking water with a morbidity on the class of diseases of the blood system was established on the basis of constructing a mathematical model. The conclusion about the legitimacy of information on the effect of the oral intake of chloroform on the blood system, hematopoietic organs and certain disorders involving the immune mechanism is presented.

Publisher

Federal Scientific Center for Hygiene F.F.Erisman

Subject

Health, Toxicology and Mutagenesis,Public Health, Environmental and Occupational Health,Pollution,General Medicine

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