State of adaptive systems of the body in boys aged of 11-15 years in the process of their age development, pubertal maturation and in the dynamics of the school year

Abstract

A comprehensive study of the functional state of the sympathoadrenal system (SAS) and adrenal cortex (AC) in boys aged of 11-15 years, was carried out depending on their age, puberty stage and academic year period, on the basis of indices of the daily adrenaline (A), noradrenaline (NA), 17-ketosteroids (17-KS) and 17-oxyketosteroids (17-OKS) excretion. A certain synchronism of the manifestation offunctional activity of the SAS mediator level, glucocorticoid and androgen AC function is determined as boys grow older and during their pubertal changes. At the same time the different dynamics of the studied indices in boys aged of from 14 to 15 years and by the V puberty stage is marked. During the academic year changes of hormone and hormonal metabolite excretion, having a different focus and intensity in the age groups were observed: a significant decrease of age NA excretion and androgen metabolite indices (at 15) of 14 and 15 year-old teenagers at the end of the academic year is found out, against the backdrop of a substantial and long-term increase of glucocorticoids (February, April), with their dangerous catabolic effect on a child’s body and their depressing effect on the immune response.