POSSIBLE MECHANISMS OF THYMUS PEPTIDES ANALGESIC ENDPOINT-Reference-Cited by-同舟云学术

POSSIBLE MECHANISMS OF THYMUS PEPTIDES ANALGESIC ENDPOINT

Published:2019-02-15 Issue:1 Volume:25 Page:44-48
ISSN:2412-9100
Container-title:Medical Journal of the Russian Federation
language:
Short-container-title:Medical Journal of the Russian Federation

Author:

Novoseletskaya A. V,Kiseleva Nina M.

Abstract

Thymus polypeptides participate in stress-limiting system work. Considering that electropain stimulation is the main stress factor in many behavioral models, it is logical to assume that thymus polypeptides have analgesic activity. The objective of this research is study of opioid and serotoninergic systems role of thymus polypeptides analgesic endpoints implementation. The rats presented with tactivin and thymulin thymus peptides analgesic activity during tail withdrawal test, which is totally blocked by naloxone, and thus is based on opioid system activation. This effect is associated with appeared serotoninergic component of stress-induced analgesia. The possible mechanism of analgesic action and the role of serotoninergic system of thymus peptides were offered based on the results of the research conducted.

Publisher

ECO-Vector LLC

Subject

General Medicine

Reference18 articles.

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