THE POSSIBILITY OF USAGE MOXIFLOXACIN 0.5% SOLUTION IN PERIOPERATIVE PROPHYLAXIS IN CHILDREN

Abstract

Introduction. Nowadays the problem of postoperative endophthalmitis after intraocular operations remains unresolved. The aim of our research was to study the efficacy of a 0.5% solution of moxifloxacin in the perioperative prophylaxis of children. Material and methods. The study included 97 healthy children (113 eyes) aged from 1 month to 17 years. The swabs from conjunctival sac were taken three times. Results. The growth of microflora was detected in the conjunctival sac at 67.3% of cases. At 45.6% of cases Staphylococcus epidermidis was observed. The highest sensitivity of isolated microorganisms to Antibacterial drugs that are used topically in ophthalmology was shown to the moxifloxacin (95.8 %), ciprofloxacin (94,83%) and levofloxacin (90,5%). Staphylococcus epidermidis was discovered more often in the conjunctival cavity (53,3%, n=16) on the first swab in the second stage of the study. All microorganisms were sensitive to moxifloxacin. After taking a swab, the installation of 0.5% solution of moxifloxacin 1 drop 4 times daily the day before surgery was prescribed. The same drops were used and the second swab was taken in 1 hour and 30 minutes before surgical operation. In 9 cases (30%) Microflora was detected again, at 88.9% of the cases Staphylococcus epidermidis (n=8) was observed. 1 drop 4 times a day for 7 days of 0.5% solution of moxifloxacin was prescribed after surgery and after the course of antibiotic therapy third swab was taken. Microflora was detected in the eyes of two children also in the third study. Instillation of 0.5% solution of moxifloxacin is quite effective in the perioperative antibiotic prophylaxis of infectious complications of intraocular operations and significantly reduces the frequency of detection of microflora in the conjunctival cavity.