CLINICAL AND EPIDEMIOLOGICAL FEATURES OF INFECTIONS ECOLOGICALLY RELATED TO TICKS IN THE CHELYABINSK REGION

Abstract

An analysis of the incidence in the dynamics of years (1998-2018) showed that the leading place among infections transmitted by ixodid ticks in the Chelyabinsk region is occupied by tick-borne tick-borne borreliosis (IKB), tick-borne encephalitis (TBE) is less common. Long-term monitoring of the natural foci of TBE and IKB showed their high epizootological potential. In 2018, febrile forms prevailed in the structure of clinical forms of TBE - 61.9%, meningeal and focal forms were found in 28.5% and 9.4%, respectively. Focal forms were represented by meningoencephalitic and polioencephalomyelitis forms with the same frequency of 4.7%. In the structure of the nosological diagnosis of ICD in the South Urals, erythema forms of the disease prevail (69.5%). The detection frequency of Borrelia DNA of the pathogenic complex B.burgdorferi s.l. in the blood serum and leukocyte fraction of patients was 13%. In 4 patients, for the first time in the Chelyabinsk region, DNA of a new Borrelia miyamotoi Borrelia genotype was detected in whole blood samples and in the samples of the leukocyte fraction using PCR-RV. Phylogenetic analysis of B. miyamotoi was carried out on all sequences of glpQ and 23SrRNA gene fragments, deposited at NCBI and homologous sequences of Chelyabinsk-2018 isolates. The disease proceeded in non-erythema form, intoxication syndrome, myalgia, chills were observed in the clinical picture.