T-CELL REACTIVITY TO ANTIGENS OF STREPTOCOCCUS IN ERYZIPELAS PATIENTS ON LASER THERAPY

Abstract

Erysipelas is a widespread infectious disease, with severe hemorrhagic forms, frequent recurrence and complications. Activation of T-cell immunity by individual streptococcus antigens determines the nature of the course and outcomes of erysipelas. Laser therapy is widely used in the treatment of erysipelas, however, indications for its purpose are often empirical, laboratory criteria for indications for purpose are absent. The goal is to study the effectiveness of infrared laser therapy in terms of the dynamics of leukocyte migration in vitro in response to S. pyogenes antigens. Materials and methods. 95 patients with erysipelas (55 women and 40 men) aged 20-65 years were examined, of which 34 were with primary erysipelas of extremity, 23 were with face erysipelas, 39 were with relapsed l erysipelas of extremity. All patients received basic antibiotic therapy. Laser therapy of the local focus area was performed in 30 of them. The leukocyte migration is determined in vitro by screening test of cell migration (STCM) during stimulation with polysaccharide, surface proteins, and the antigen of L-forms of S. pyogenes in various concentrations. Results. Laser therapy of patients with erysipelas had a noticeable immunomodulatory effect in the reaction of blood cells to the polysaccharide and surface proteins. At the same time, in patients with erythematous-hemorrhagic form of erysipelas, the clinical effect was manifested in a shorter duration of erythema, edema, hemorrhages, and regional lymphadenitis. Conclusion. The STCM method, which makes it possible to evaluate the migration of leukocytes to the surface specific antigens of streptococcus, can be used as a screening method for patients with erysipelas, in whom laser therapy may have a more pronounced effect.