Hydradenitis suppurativa: etiology, pathogenesis and treatment

Abstract

Hydradenitis suppurativa is a multifactorial disease. The pathogenesis has not been well studied yet. The views about antecedence of lesions of structural elements of the skin are disputable and that is what determines the actuality of scientific studies in this field. The article presents literature review on modern data regarding prevalence and etiology of the disease. The classification of clinical features and Satorius score for quantitating the severity of the disease, the methods of diagnosis (bacteriological, immunopathological and etc.) are suggested. The role of the genetic, comorbid factors, metabolic and hormonal disorders and the immune system part in the development of the disease are discussed. Topical and systemic medications with the primary purpose of reducing bacterial load, elimination offollicular occlusion, normalization of immune response, correction of hormonal status, improvement of skin defects healing, pain syndrome removal, improving the quality of life ofpatients, are suggested for the therapy.