Biochemical indices of urine in children with allergic diseases of airways

Abstract

Currently, unsatisfactory control of the course of allergic diseases of airways (ADA) remains. There is data on the potential involvement of urate and oxalate metabolism in the pathogenesis of ADA, which determines the need to study the corresponding biomarkers. Aim of the work - to evaluate the daily urinary excretion of urates and oxalates in ADA children. Materials and methods. We examined 100 children aged 2 to 9 years, boys - 22, girls - 78, with symptoms of crystalluria. The children were divided into the main group (42 children) and the comparison group (58 people). The main group included patients with established diagnoses of ADA, and the comparison group included patients without ADA. A biochemical study of daily urine was performed in all cases. Results. It was found that the daily excretion of oxalates in ADA patients was significantly increased compared to the control, 26.5 [22.1; 32.6] mg/day and 23.3 [20.1; 27.6] mg/day, respectively. Daily urate excretion in patients of the main group was also significantly increased compared to the control, both in absolute numbers - 1.45 [1.13; 2.13] mmol/day and 1.17 [0.89; 1.5] mmol/day, respectively (p = 0.005), and in normalized to the body surface area units. Conclusion. A statistically significant increase in daily urate excretion was found in ADA children. The clinical and pathogenetic significance of this phenomenon in children with ADA requires further study.