EPIDEMIOLOGY, ETIOPATHOGENESIS, COMORBIDITY IN PSORIASIS - NEW FACTS

Abstract

Psoriasis vulgaris is a chronic recurrent genetically determined dermatosis with multifactorial nature, characterized by hyperproliferation and impaired differentiation of keratinocytes, inflammatory reaction in the dermis, immune disorders and lesions of the skin, nails, joints and other organs. The article presents a review of the current literature data on the etiology and pathogenesis of psoriasis and its association with various comorbidities, psycho-emotional and socio-economic status. Among the most common comorbidities, depending on the severity of psoriasis, there are cardiovascular diseases, diabetes mellitus, metabolic syndrome. In addition, psoriasis vulgaris often affects people of working age, leading to psychological and social desadaptation, decrease of work capacity, depressive disorder.