Affiliation:
1. National Scientific and Practical Center of Children’s Health
Abstract
The review presents modern non-invasive methods for diagnosing liver fibrosis in children. The tests of biochemical diagnostics of fibrosis are described, the structure of the liver parenchyma and degree of fibrosis are evaluated with the use of the traditional ultrasound technique and non-invasive quantitative evaluation of the liver structure: Acoustic Structure Quantification (ASQ) with the assessment of the density index (DI). ASQ is shown to allow receive valuable information on the acoustic structure of liver tissue in visual, parametric and numerical formats, that increases the quality, level and clinical significance of the diagnosis. Authors recommend this non-invasive method to determine the stages of liver fibrosis and subsequent long-term follow-up and monitoring of the effectiveness of its comprehensive therapy. The possibilities of magnetic resonance imaging in diagnosis of fibrosis and liver cirrhosis in children are also underlined.
Publisher
National Medical Research Center for Childrens Health
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