Congenital cleft of the lip and palate in children: pathogenetical significance of matrix metalloproteinases

Author:

Mardanov Ayaz E.1,Smirnov I. E.2,Mamedov A. A.1

Affiliation:

1. I.M. Sechenov First Moscow State Medical University

2. Scientific Centre of Children Health

Abstract

There are presented data about the prevalence offormation of congenital cleft lip and palate (CCLP) - one of the most common birth defects of the maxillofacial region in children. According to WHO the occurrence of children born with CCLP in the world is 0,6-1,6 cases per 1,000 live births, and varies greatly from the region to region and ethnic group residing there. At the same time, in 63,1% of patients there were established chromosomal abnormalities, and in 36,9% - non-chromosomal syndromes. In Russia, every year there are occurred from 3,5 to 5 thousand children with such defects that requires the development of new methods ofprevention of these malformations. There are reported modern views on the pathogenetical and potent diagnostic significance of the evaluation of the content of tissue matrix metalloproteinases (MMPs) and their inhibitors in mechanisms of the formation of CCLP, shown the probable associations of changes in the expression or activity of MMP and TIMP with various forms of malformations of the palate and upper jaw.

Publisher

National Medical Research Center for Childrens Health

Reference73 articles.

1. Mamedov A.A., Supiev T.K., Negametzyanov N.G. Vrozhdennaya rasshchelina verkhnei guby i neba. Almaty: KazNMU; 2013.

2. Mamedov A.A. Vrozhdennaya rasshchelina neba i puti ee ustraneniya. M.: Detstomizdat; 1998.

3. Artyushkevich A.S., Grichanyuk D.A., Vismont F.I., Artyushkevich S.A. Vrozhdennye rasshcheliny verkhnei guby i neba: sovremennye aspekty khirurgicheskogo lecheniya. Sovremennaya stomatologiya. 2004; (2): 20-5.

4. Crockett D.J., Goudy S.L. Cleft lip and palate. Fac. Plast. Surg. Clin. N. Am. 2014; 22 (4): 573-86.

5. Kolker A.R., Sailon A.M., Meara J.G., Holmes A.D. Midline cleft lip and bifid nose deformity: description, classification, and treatment. J Craniofac Surg. 2015; 26 (8): 2304-8.

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3