Systemic lupus erythematosus in the practice of dermatology.

Abstract

Systemic lupus erythematosus (SLE) - an autoimmune disease of unknown etiology with multivariate manifestations, course and prognosis characterized by hyperproduction wide spectrum of organ autoantibodies and immune complexes that cause immunological damage to internal organs with the development of multiple organ failure Increased frequency of occurrence of the manifestations of autoimmune disease in dermatology practice, the complexity of creating diagnostic algorithms and untimely appointment of targeted erapii put this problem in a number of the most pressing. Skin rashes are often the leading symptom in the clinical picture of most cases of SLE. In the 20-33% of cases of SLE begins with cutaneous manifestations of the syndrome, with the result that patients are directed to the primary dermatological reception Submitted 3 clinical observation of patients with systemic lupus erythematosus, the diagnosis of which require a comprehensive survey to include histological examination of skin biopsies and immunological studies: blood analysis antinuclear factor on HEp-2 cells with determination of the type nucleus luminescence lupus anticoagulant in blood plasma, IgG antibodies to phospholipids and Ig class , Double-stranded DNA, antinuclear antibody class IgG, IgG autoantibodies to AMA-M2 (by immuno-blot), antibodies to cardiolipin and lupus anticoagulant. Due to the fact that in practice the conducting patients RAC no standardized criteria for determining the severity and degree of disease activity, use of prognostic indicators (clinical, laboratory and constitutional parameters) unfavorable course of RAC in dermatology practice would improve the quality of diagnosis. Thus, we have presented clinical studies have shown that early diagnosis of this disease is the determining factor of a favorable prognosis of the disease.