Comorbidity of chronic obstructive pulmonary disease and ischemic stroke.

Abstract

This review summarizes the literature on the problem of comorbidity of chronic obstructive pulmonary disease (COPD) and ischemic stroke (IS). The basic mechanisms of interrelation of these diseases. According to various sources the prevalence of IS in patients with COPD by 20% higher than in the general population. COPD and IS have common risk factors, the main of which is considered the age and smoking. Such manifestations of COPD such as chronic systemic inflammation (HSV), oxidative stress, accelerated atherogenesis, increased thrombotic risk events, arterial hypoxemia and hypercapnia may also influence the frequency of occurrence of IS. The importance given to the role in the development of COPD, certain subtypes of IS. Thus, HSV increases the intensity of the processes of atherogenesis and causes destabilization of atherosclerotic plaques, which increases the risk of developing atherothrombotic subtype of IS. COPD is a major factor of vascular comorbidity, promotes hemodynamic and cardioembolic subtype IS. It is therefore evident that a more frequent occurrence of ischemic central nervous system damage in patients with COPD compared to the general population is the result of the combined effect on cerebral blood flow and brain morphological structure of multiple pathogenic factors associated with systemic manifestations of the disease. Therapy options for comorbid COPD and IS flow needs to be improved. Thus, further study of comorbidity of COPD and AI mechanisms, understanding of the role and place of the respiratory and cerebrovascular syntropy, in the development of these diseases opens up prospects for the implementation of modern strategies of rational therapy.